diphenyliodonium

RN given refers to the parent coumpound; inhibitor of neutrophil superoxide generating oxidase; structure has been determined

Also Known As:

diphenyliodonium bromide; diphenyliodonium chloride; diphenyliodonium hexafluoroarsenate; diphenyliodonium hexafluorophosphate; diphenyliodonium iodide; diphenyliodonium nitrate; diphenyliodonium nitrite; diphenyliodonium sulfate (1:1); diphenyliodonium tosylate; iodonium biphenyl; iodoniumdiphenyl

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        diphenyliodonium: 14
- Onium Compounds
  - diphenyliodonium: 14

Experts

1.	Chansaenpak, Kantapat: 1 article (08/2021)
2.	Duangkamol, Chuthamat: 1 article (08/2021)
3.	Kamkaew, Anyanee: 1 article (08/2021)
4.	Lai, Rung-Yi: 1 article (08/2021)
5.	Ngivprom, Utumporn: 1 article (08/2021)
6.	Noisa, Parinya: 1 article (08/2021)
7.	Pewklang, Thitima: 1 article (08/2021)
8.	Sukwattanasinitt, Mongkol: 1 article (08/2021)
9.	Wangngae, Sirilak: 1 article (08/2021)
10.	Wet-Osot, Sirawit: 1 article (08/2021)

Related Diseases

1.	Necrosis 01/01/2004 - "Pretreatment of the cells with inhibitors of NADPH oxidase, including diphenyliodonium chloride, apocynin, N-vanillylnonanamide and staurosporine was effective in lowering the menadione-induced elevations of superoxide, and also in the suppression of the switch of the cell death mode from apoptosis to necrosis in menadione-treated cells except for the case of staurosporine. "
2.	Hypoxia (Hypoxemia) 08/15/2021 - "Compared to the normal condition, the fluorescence intensity in hypoxic conditions increased about 10-fold after 15 min. Prolonged incubation showed a 26-fold higher fluorescent intensity after 60 min. In addition, the fluorescence signal under hypoxia can be suppressed by an electron transport process inhibitor, diphenyliodonium chloride (DPIC), suggesting that reductases take part in the azo group reduction of AZO-Flav in a hypoxic environment. " 05/15/2014 - "SN29428 activation under hypoxia was strongly attenuated by the pan-flavoprotein inhibitor diphenyliodonium, but less so by knockout of POR suggesting other flavoreductases contribute. " 12/01/1997 - "On the other hand, 100 microM diphenyliodonium (DPI) inhibited the ischemia-mediated increase in lung fluorescence by 69% and lung TBARS by 70%, but it had no effect on the increase with anoxia-reoxygenation. " 10/01/2005 - "3. Diphenyliodonium, an inhibitor of NADPH oxidase, had no effect on the hypoxia-evoked closure of K+ channels in primary AMCC, whereas the mitochondrial inhibitor rotenone abolished the hypoxia-evoked response. " 11/01/2004 - "The response to reoxygenation, but not that to hypoxia, was inhibited by the antioxidant dithiothreitol (DTT) and the NAD(P)H-oxidase inhibitor diphenyliodonium (DPI). "
3.	Nephrotic Syndrome (Syndrome, Nephrotic) 10/01/2017 - "Ex vivo DNA synthesis in PDGF-stimulated PBL was significantly (P<0.01) reduced in patients with INS; however, diphenyliodonium, an inhibitor of NOX, markedly corrected impairment in growth factor-induced BrdU incorporation.ConclusionsThese results show that NOX activation might have a role in regulation of lymphocytic activity in patients with INS through the impairment of PDGF mitogenic function and might contribute toward pathogenesis of nephrotic syndrome."
4.	Nematode Infections 10/21/2023 - "The addition of paclobutrazol, which reduces salicylic acid (SA) levels in cells, and diphenyliodonium chloride, which inhibits superoxide generation, completely abolished the repressive effect of Myco on nematode infection. "
5.	Ischemia 12/01/1997 - "On the other hand, 100 microM diphenyliodonium (DPI) inhibited the ischemia-mediated increase in lung fluorescence by 69% and lung TBARS by 70%, but it had no effect on the increase with anoxia-reoxygenation. "

Related Drugs and Biologics

1.	NADPH Oxidases (NAD(P)H oxidase)
2.	Superoxides (Superoxide)
3.	Vitamin K 3 (Menadione)
4.	Staurosporine
5.	acetovanillone (apocynin)
6.	vanillyl-N-nonylamide
7.	Antioxidants
8.	Catalase
9.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)