pyrazole

06/01/2013 - "3-(4-Fluorophenyl)-N-(4-bromophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4c) was found to be the most active compound of the series showing 75% (3/4, 0.25-2.0 h) and 50% (2/4, 4.0 h) protection against minimal clonic seizure at 100 mg/kg without any toxicity. "
12/01/2012 - "In anticonvulsant screening, 3-(4-fluorophenyl)-N-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (D09) showed maximum activity showing 100% (4/4, 0.25-0.5h) and 75% (3/4, 1.0 h) protection against minimal clonic seizure test without any toxicity."
07/01/1997 - "A third experiment was designed to assess the effects of repeated pyrazole administration on the potentiated withdrawal seizure response. "
07/01/1986 - "WSP mice also showed slightly more severe convulsions than WSR mice when treated with saline or pyrazole alone. "
06/01/1981 - "Pyrazole exacerbates handling-induced convulsions in mice."

02/26/2015 - "The pyrazole-scaffold compound displayed excellent metabolic stability and was highly effective in suppressing solid tumor growth in vivo. "
11/01/2014 - "During previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. "
10/01/1980 - "In a phase I trial, 2,3-dihydro-1H-imidazo[1,2-b]pyrazole was administered iv weekly at doses ranging from 0.1 to 3.0 g/m2/wk to patients with refractory metastatic solid tumors. "
09/01/2015 - "N-(β-D-ribofuranosyl)- and N-(β-D-xylofuranosyl)-6{[(1E)-4-chlorophenyl)-methylene] amino}4-(4-florophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile (6a,b) were the most active compounds against three human cancer cell lines. "
09/01/2015 - "Synthesis and apoptotic activity of new pyrazole derivatives in cancer cell lines."

01/01/2014 - "Data from this study provide evidence that these new pyrazole formulations could be an alternative source for the treatment of fungal infections caused by Candida. "
04/01/2009 - "Animals were infected with Leishmania amazonensis and treated two weeks after the parasitic infection with the pyrazole carbohydrazides for 45 days. "
02/01/2013 - "Recently, we showed that oral treatment with synthetic pyrazole carbohydrazide compounds induced lower parasite load in draining lymph nodes and reduced skin lesion size without causing any toxic effects in an experimental murine infection model with Leishmania amazonensis. "
04/01/2009 - "Effect of oral treatment with pyrazole carbohydrazide derivatives against murine infection by Leishmania amazonensis."
03/01/1981 - "Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection."

03/01/1977 - "Investigations into the effects of pyrazole and 3-AT pretreatment on the acute toxicity and hepatotoxicity of DMN showed that pyrazole significantly increased the median lethal dose (LD50) of DMN and provided substantial protection against the hepatotoxicity of DMN, in that centriblobular necrosis was not seen at dose levels of DMN up to 25 mg/kg and early histochemical changes indicative of liver injury were not observed at a dose level of 15 mg DMN/kg. In contrast, 3-AT pretreatment did not affect the LD50 of DMN or provide any protection against the hepatotoxicity of DMN. "
02/01/2009 - "CsA also prevented pyrazole plus LPS-induced hepatocyte necrosis. "
07/01/2007 - "Pyrazole treatment of ob/ob mice for 2 days caused necrosis, steatosis, and elevated serum transaminase and triglyceride levels compared with saline ob/ob mice. "
08/01/2005 - "These results show that pyrazole treatment enhanced LPS-induced necrosis, not apoptosis. "
08/01/2005 - "Pathological evaluation showed severe inflammatory responses and necroses only in liver sections from rats in the pyrazole plus LPS group; blood transaminase levels were significantly elevated only in the combination group. "

03/03/2003 - "We compared the influence of acute inflammation elicited in vivo by bacterial endotoxin lipopolysaccharide (LPS) and liver injury caused by the hepatotoxin pyrazole on hepatic Cyp2a5 expression in mice. "
03/03/2003 - "Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression."
05/31/1963 - "[ACTION OF A PYRAZOLE DERIVATIVE IN MEDICAL AND SURGICAL INFLAMMATIONS OF THE UPPER RESPIRATORY TRACT]."
10/01/1963 - "[CLINICAL EXPERIENCE WITH THE ACTION OF A COMBINATION OF A PYRAZOLE DERIVATIVE AND DELAYED-ACTION SULFONAMIDE IN ACUTE INFLAMMATION OF THE UPPER RESPIRATORY TRACT AND IN INFLUENZA]."
08/01/2012 - "Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling."