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1,3-dimethyluric acid

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - Uric Acid: 17354
      - 1,3-dimethyluric acid: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        Uric Acid: 17354
        1,3-dimethyluric acid: 9

Experts

1.	Kim, Sang Geon: 2 articles (09/2005 - 12/2002)
2.	Kim, So Hee: 2 articles (09/2005 - 12/2002)
3.	Lee, Myung Gull: 2 articles (09/2005 - 12/2002)
4.	Hori, Seiji: 1 article (04/2008)
5.	Kizu, Junko: 1 article (04/2008)
6.	Terajima, Tomoko: 1 article (04/2008)
7.	Tsuchiya, Masao: 1 article (04/2008)
8.	Watanabe, Shigekazu: 1 article (04/2008)
9.	Yamakami, Jun: 1 article (04/2008)
10.	De Martin, Sara: 1 article (05/2006)

Related Diseases

1.	Renal Insufficiency (Renal Failure) 12/01/2002 - "In rats with renal failure, the plasma concentrations of 1,3-dimethyluric acid were considerably higher and the resultant AUC(0-6 h) of 1,3-dimethyluric acid was significantly greater (44.4 vs 456 microg min mL(-1)) compared with control rats. " 12/01/2002 - "The in-vitro intrinsic 1,3-dimethyluric acid formation clearance was significantly faster in rats with renal failure (734 vs 529 10(-6) mL min(-1)) compared with control rats using hepatic microsomal fraction. " 12/01/2002 - "Hence, it was expected that the formation of 1,3-dimethyluric acid would show an increase in rats with renal failure as a result of induction of CYP2E1. " 12/01/2002 - "The results led us to conclude that in rats with uranyl nitrate-induced renal failure after the administration of aminophylline, 5 mg kg(-1) as theophylline, there was an increase in the formation of 1,3-dimethyluric acid as a result of an increase in CYP2E1 expression."
2.	Acute Kidney Injury (Acute Renal Failure) 12/01/2002 - "Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation."
3.	Seizures (Absence Seizure) 03/01/1986 - "Direct i.v. infusion of either 1-methyluric acid, 1,3-dimethyluric acid or 3-methylxanthine did not produce seizures despite high concentrations in serum. "
4.	Periodontitis 10/10/2023 - "Additionally, for urinary caffeine metabolites, there was a significant positive association between 1-methyluric acid (1-MU), 1,3-dimethyluric acid (1,3-DMU), 3,7-dimethyluric acid (3,7-DMU), 1,7-dimethylxanthine (1,7-DMX), or 5-actlyamino-6-amino-3-methyluracil (AAMU) and periodontitis, with adjusted odds ratios and 95% confidence intervals of 1.10 (1.02, 1.19), 1.86 (1.05, 3.29), 0.94 (0.90, 0.98), 1.29 (1.03, 1.62), and 1.15 (1.05, 1.26), respectively. "
5.	Fibrosis (Cirrhosis) 05/01/2006 - "Inhibition of 1,3-dimethyluric acid formation, which is catalyzed by CYP1A2 and CYP2E1, progressively decreased from 58% in healthy subjects to 43% and 7% in patients with mild cirrhosis and those with severe cirrhosis, respectively. "

Related Drugs and Biologics

1.	Theophylline (Theon)
2.	1-methyluric acid
3.	3-methylxanthine
4.	Cytochrome P-450 CYP2E1 (CYP2E1)
5.	Cytochrome P-450 CYP1A2 (CYP1A2)
6.	Caffeine (No Doz)
7.	Aminophylline (Carine)
8.	1-methylxanthine
9.	Verapamil (Calan)
10.	Uranyl Nitrate

Related Therapies and Procedures

1.	Oral Administration