bimolane

12/01/1991 - "Efficacy of bimolane in the Malassezia ovalis model of psoriasis."
02/01/2020 - "Chronic myeloid leukaemia in a patient with psoriasis following bimolane treatment."
12/09/1997 - "Bimolane is a member of the bis(2,6-dioxopiperazine) class of drugs and has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. "
12/24/2011 - "Bimolane has been commonly used in China for the treatment of psoriasis and various types of cancer. "
11/01/1992 - "They had all suffered from psoriasis and received bimolane treatment before the occurrence of their leukemia. "

07/01/1993 - "These results suggested that protection against cardiotoxicity of doxorubicin afforded by probimane, bimolane, and dexrazoxane may be related to their ability to combine with the complex iron so that the iron was no longer able to take part in free radical reactions."

12/24/2011 - "Our studies indicate that bimolane effectively induces a variety of cellular and chromosomal changes in cultured lymphocytes and that similar alterations occurring in bone marrow stem cells could contribute to the development of the secondary cancers seen in bimolane-treated patients."
06/01/1985 - "These cell culture data may be useful for further in vivo tumor studies to determine the therapeutic index of combined radiation and AT 1727."
12/24/2011 - "Bimolane has been commonly used in China for the treatment of psoriasis and various types of cancer. "
01/01/1992 - "In this paper the authors studied quantitatively the micronucleus formation at various phases of interphase in human lymphocytes induced by chemical mutagens by means of control of cell culture intervals, autoradiography and block of metaphase cells etc. The results show that mutagenic anti-tumor drugs: bimolane (treatment in vitro) and thio-tepa etc. (treatment in vivo) can induce micronucleus formation at various phases of interphase in lymphocytes. "
04/01/1985 - "The antitumor activities of three new analogs were compared with bimolane, ICRF-154 and razoxane against four rodent tumors. "

12/24/2011 - "Although bimolane has been identified as a human leukemia-inducing agent, little is known about its genotoxic effects, and a systematic study of the types of chromosomal alterations induced by this compound has not been performed. "
10/01/1993 - "[140 cases of acute leukemia caused by bimolane]."
12/24/2011 - "Patients treated with bimolane have been reported to have an increased risk of developing therapy-related leukemias. "
11/01/1992 - "The interval between the initiation of bimolane therapy and the diagnosis of leukemia was 12-96 months (median 30 months). "
11/01/1992 - "They had all suffered from psoriasis and received bimolane treatment before the occurrence of their leukemia. "

11/01/1992 - "This paper reports for the first time results of cytogenetic studies on 14 consecutive secondary acute non-lymphocytic leukemia (S-ANLL) induced by bimolane therapy. "
11/01/1992 - "This study indicates that: (1) bimolane is a causative factor of leukemia in this series; (2) the leukemia in our series is therapy-related leukemia (TRL) rather than de novo ANLL; (3) there exists, in fact, a new subgroup of TRL characterized by specific rearrangements, whose clinical, hematological and prognostic features and pathogenetic mechanism may be different from classical TRL characterized by chromosome abnormalities involving absence or deletion of parts of chromosome 5 and/or 7."
02/01/1997 - "Translocation t(7;11)(P15;P15) in a patient with therapy-related acute myeloid leukemia following bimolane and ICRF-154 treatment for psoriasis."