cecropin A

from cecropia moth, Hyalophora cecropia; small basic protein; has potent antibacterial activity against E coli & other Gram-negative bacteria; structure given in first source; also prevents development of malarial oocysts in mosquito vector

Also Known As:

cecA1 protein, Drosophila; cecA2 protein, Drosophila; cecropin A1 protein, Drosophila; cecropin A2 protein, Drosphila; dsim protein, Drosophila; dyak protein, Drosophila; Cecropin A

Networked: 40 relevant articles (6 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        cecropin A: 40
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - cecropin A: 40
  - Antimicrobial Cationic Peptides: 414
    - cecropin A: 40

Experts

1.	Deng, Baichuan: 2 articles (01/2020 - 01/2019)
2.	Deng, Jinping: 2 articles (01/2020 - 01/2019)
3.	Ni, Xiaojun: 2 articles (01/2020 - 01/2019)
4.	Sheehan, Gerard: 2 articles (01/2020 - 01/2018)
5.	Xin, Zhongquan: 2 articles (01/2020 - 01/2019)
6.	Zhai, Zhenya: 2 articles (01/2020 - 01/2019)
7.	Zhang, Fan: 2 articles (01/2020 - 01/2019)
8.	Campo, Sonia: 2 articles (04/2014 - 08/2008)
9.	San Segundo, Blanca: 2 articles (04/2014 - 08/2008)
10.	Kokoza, Vladimir: 2 articles (05/2010 - 04/2009)

Related Diseases

1.	Infections 01/01/2015 - "In this work, we expressed Bombyx mori (Bm) cecropin-A in mealworms by the infection of transformed entomopathogenic Beauveria bassiana ERL1170. " 04/22/2014 - "Furthermore, transgenic cecropin A seeds exhibited resistance to infection by fungal and bacterial pathogens (Fusarium verticillioides and Dickeya dadantii, respectively) indicating that the in planta-produced cecropin A is biologically active. " 06/01/2012 - "All AMPs (CaLL, PEG-CaLL, LL-37, cecropin A) delivered to the lung by airway administration showed limited (<3%) pulmonary absorption in the IPRL with extensive AMP accumulation in lung tissue itself, a characteristic anticipated to be beneficial for the treatment of pulmonary infections. " 01/01/2021 - "Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti." 04/01/2009 - "Consistently, RNAi knockdown of REL2 in wild-type mosquitoes results in a delay in Defensin A and Cecropin A expression in response to infection and in increased susceptibility to both bacteria and P. "
2.	Sepsis (Septicemia) 01/01/2020 - "While Drosomycin and cecropin A expression increased in sepsis survivors, DCA treatment decreased both and selectively increased defensin." 11/01/2011 - "Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii."
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "We show that Melittin and the hybrid are most effective against the 3D colorectal cancer cells compared to Cecropin A." 01/01/2023 - "Here, we report the effects induced by several AMPs, Melittin, Cecropin A, and a Cecropin A-Melittin hybrid, against two human colorectal cancer-derived spheroids. "
4.	Septic Shock (Toxic Shock Syndrome) 09/01/2001 - "To investigate the efficacy of three cecropins, cecropin A, cecropin B, and cecropin P1, in preventing lethality in a rat model of septic shock. "
5.	Gastroenteritis 09/05/2014 - "Cecropin A-melittin mutant with improved proteolytic stability and enhanced antimicrobial activity against bacteria and fungi associated with gastroenteritis in vitro."

Related Drugs and Biologics

1.	Melitten (Melittin)
2.	Gentamicins (Gentamicin)
3.	Peptides (Polypeptides)
4.	Cecropins
5.	cecropin P1-LI
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Adenosine Monophosphate (AMP)
8.	Insecta cecropin B protein
9.	Antimicrobial Peptides
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)