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AICA ribonucleotide (CAIR)

Subscribe to New Research on AICA ribonucleotide

RN given refers to beta-D-ribofuranosyl isomer; purine precursor; has antineoplastic activity; AICAR is also used as an abbreviation for AICA riboside

Also Known As:

CAIR; ZMP; 4-carboxy-5-aminoimidazole ribotide; 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide; 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate; 5-amino-4-imidazolecarboxamide ribofuranoside 5'-monophosphate; AICA ribonucleotide, (D-ribofuranosyl)-isomer; AICAR; AICAriboside 5'-monophosphate; Z-nucleotide; aminoimidazole carboxamide ribonucleotide

Networked: 314 relevant articles (28 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Singh, Inderjit: 7 articles (01/2007 - 09/2004)
2.	Viollet, Benoit: 6 articles (01/2014 - 02/2007)
3.	Suwinski, Rafal: 6 articles (03/2013 - 10/2005)
4.	Giri, Shailendra: 5 articles (01/2014 - 07/2005)
5.	Kemp, Bruce E: 5 articles (11/2010 - 05/2002)
6.	Singh, Avtar K: 5 articles (08/2006 - 07/2005)
7.	Tarnawski, Rafal: 4 articles (03/2013 - 03/2003)
8.	Skladowski, Krzysztof: 4 articles (03/2013 - 03/2003)
9.	Miller, Joan W: 4 articles (01/2013 - 08/2010)
10.	Morizane, Yuki: 4 articles (01/2013 - 08/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2010 - "Tumor samples from 148 patients (72 p-CF and 76 p-CAIR patients) were available for molecular studies. " 12/01/2007 - "The aim of the present study was to determine the effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) on proliferation, cell cycle, and apoptosis in the human epithelial cervical cancer cell line CaSki cells. " 01/01/2013 - "Tumors isolated from mice treated with AICAR had decreased expression of Ki67 and increased apoptotic cells (TUNEL positive) compared with the control. " 02/01/2012 - "5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), a well-known AMPK activator, also inhibited tumor cell adhesion and invasion and reduced the expression of epithelial to mesenchymal transition (EMT)-related genes. " 01/01/2012 - "By contrast, tumors with low intensity of PTEN did not gain from p-CAIR (5-year LRC 56.2% vs. 47.2%, p = 0.49, RR = 0.94). "
2.	Inflammation 04/01/2015 - "These results indicated that the AMPK activator AICAR effectively suppressed the inflammatory responses and alleviated liver damage induced by CCl4, implying that AMPK activation might be beneficial for ameliorating inflammation-based liver damage. " 01/01/2015 - "However, little information is available on the effects of AICAR on the clearance of apoptotic cells by macrophages, known as efferocytosis, which is essential in maintaining tissue homeostasis and resolving inflammation. " 11/01/2007 - "This study investigated the inhibitory effects of AICAR as an anti-inflammatory modulator on allergic airway inflammation in murine animal models. " 09/01/2015 - "As a result, salicylate and AICAR inhibited inflammation and reduced cell apoptosis. " 07/30/2015 - "At the time-points where we observed equivalent running- and AICAR-induced muscle pAMPK levels (7 and 14 days), cell proliferation, synaptic plasticity and gene expression, as well as markers of oxidative stress and inflammation in the dentate gyrus (DG) of the hippocampus and lateral entorhinal cortex (LEC) were evaluated. "
3.	Ischemia 11/01/2006 - "We confirmed that AICAR (0.5 mM) applied 10 min prior to a 30-min period of ischemia and present throughout ischemia and reperfusion caused a substantial improvement in the recovery of developed pressure on reperfusion. " 01/01/2014 - "AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion." 12/01/2001 - "The administration of an AMPK activator, AICAR, before ischemia simulated the benefits of preconditioning on energy metabolism and hepatic injury. " 12/01/2000 - "AICAR attenuated the permeability increase (p < .05) and attenuated mucosa, but not serosal, ischemia (p < .05). " 01/01/1992 - "These results demonstrate that AICAr was unable to limit myocyte necrosis when administered either before ischemia or before coronary reperfusion in this experimental preparation of acute myocardial infarction."
4.	Insulin Resistance 01/01/2012 - "Here we aim to determine whether the therapeutic effects of AICAR against insulin resistance involve its anti-inflammatory function, which requires macrophage SIRT1. " 01/01/2012 - "AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), which has been shown to reduce insulin resistance in various animal models. " 11/04/2011 - "AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle." 06/01/2010 - "Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment." 09/01/2009 - "Our data implicates reductions in mTOR complex activation with the reversal of lipid-induced skeletal muscle insulin resistance in response to exercise training or AICAR and identifies mTOR as a potential target for the treatment of insulin resistance."
5.	Body Weight (Weight, Body) 09/01/2012 - "PD reduced both body weight and fat volume; consequently, lipid metabolism was improved by increasing AMPKα, similar to AICAR, and reduced PPARγ2 and C/EBPα expression in adipose tissue. " 01/01/2006 - "In vivo study, treated and untreated mice with AICAR (0.1-0.5 mg/g body weight) were fed high-fat diet (60% kcal% fat) to induce DIO and several parameters were studied. " 09/01/2014 - "AICAR increased body weight and epididymal and retroperitoneal fat mass by increasing energy intake for the first 2 weeks and decreasing energy expenditure, whereas compound C reversed the AICAR effect on energy metabolism. " 08/01/2011 - "These results suggest genetic variation in feeding response for central AICAR and Compound C in chickens, which may contribute to the different body weights between the HWS and LWS lines." 08/01/2011 - "Our aim was to investigate the effect of intracerebroventricular (ICV) administration of AMPK stimulator AICAR and AMPK inhibitor Compound C on food intake in lines of chickens that had undergone long-term selection from a common founder population for high (HWS) or low (LWS) body weight. "

Related Drugs and Biologics

1.	Metformin (Glucophage)
2.	acadesine
3.	AICA ribonucleotide (CAIR)
4.	Adenosine
5.	AMP-Activated Protein Kinases
6.	Insulin (Novolin)
7.	Glucose (Dextrose)
8.	purine
9.	Sirolimus (Rapamycin)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Resuscitation
2.	Radiotherapy
3.	Intraperitoneal Injections
4.	Carotid Endarterectomy
5.	Kidney Transplantation