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geranylgeranylacetone (teprenone)

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structure in first source; RN given refers to isomeric cpd without isomeric designation; mixture of (5E,9E,13E) & (5Z,9E,13E)-isomers

Also Known As:

teprenone; 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one; geranyl-geranyl-acetone; geranylgeranylacetone, (E,E,E)-isomer; geranylgeranylacetone, (Z,E,E)-isomer; teprenon; tetraprenyl acetone; tetraprenylacetone

Networked: 166 relevant articles (14 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Terpenes: 260
    - Diterpenes: 237
      - geranylgeranylacetone: 166

Experts

1.	Fujiki, Minoru: 7 articles (05/2010 - 09/2004)
2.	Kobayashi, Hidenori: 7 articles (05/2010 - 09/2004)
3.	Mizushima, Tohru: 6 articles (01/2013 - 04/2007)
4.	Abe, Tatsuya: 5 articles (05/2010 - 02/2005)
5.	Takahashi, Naohiko: 5 articles (12/2009 - 07/2003)
6.	Hoshino, Tatsuya: 4 articles (01/2013 - 06/2005)
7.	Ishii, Keisuke: 4 articles (05/2010 - 09/2004)
8.	Ooie, Tatsuhiko: 4 articles (09/2007 - 07/2003)
9.	Saikawa, Tetsunori: 4 articles (09/2007 - 07/2003)
10.	Uchida, Susumu: 4 articles (07/2006 - 02/2005)

Related Diseases

1.	Ischemia 09/10/2004 - "Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia." 09/01/2007 - "Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart." 06/01/2005 - "Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart." 01/01/2007 - "This study was conducted to assess the effects of geranylgeranylacetone (GGA) on ischemia-induced retinal injury. " 01/01/2007 - "Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury."
2.	Reperfusion Injury 07/01/2009 - "It has been shown that induction of HSP70 by administration of geranylgeranylacetone (GGA) leads to protection against ischemia/reperfusion injury. " 09/28/2005 - "Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers." 03/02/2015 - "Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved." 02/01/2012 - "Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats." 06/01/2000 - "Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers."
3.	Wounds and Injuries (Trauma) 01/01/2009 - "We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE). " 02/01/2013 - "We investigated the beneficial effects of a pharmacological treatment with geranylgeranylacetone (GGA) on keratinocytes using in vitro scratch wound injury assay in nonirradiated and irradiated conditions. " 06/01/2010 - "Geranylgeranylacetone (GGA) is known to protect the cochlea from various injuries. " 07/01/1992 - "These findings suggest that teprenone alleviates hepatocellular injuries. " 01/01/2009 - "Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study."
4.	Ulcer 06/15/2015 - "Geranylgeranylacetone (GGA), an anti-ulcer drug, induces HSP70 and thereby protects against cellular damage in various diseases. " 06/01/2015 - "Geranylgeranylacetone (GGA) has been clinically used as an anti-ulcer drug. " 04/01/2015 - "Geranylgeranylacetone (GGA), an isoprenoid compound, is an anti-ulcer drug developed in Japan. " 01/01/2013 - "Since geranylgeranylacetone has already been approved for use as an anti-ulcer drug and its safety in humans has been confirmed, we propose that this drug be considered as a candidate drug for the prevention of AD. " 11/01/2011 - "Geranylgeranylacetone (GGA) has been used as an anti-ulcer drug in Japan for more than 20 years. "
5.	Shock 01/01/2010 - "To study the effects of geranylgeranylacetone (GGA) on the expression of heat shock protein70 (HSP70) on retinal ganglion cells (RGC) in rats with chronic intraocular pressure (IOP) elevation. " 06/01/2015 - "Also, boosting of HSPs, by the heat shock factor-1 activator geranylgeranylacetone, halted AF initiation and progression in experimental cardiomyocyte and dog models for AF. " 12/08/2006 - "These reductions were prevented by HSP-inducing pretreatments: mild heat shock, geranylgeranylacetone (GGA), and transfection with human HSP27 or the phosphorylation-mimicking HSP27-DDD. " 09/01/2006 - "Hsp overexpression was accomplished by a mild heat shock or by the drug geranylgeranylacetone (GGA). " 11/01/2000 - "Induction of heat shock protein-70 (hsp-70) by intraarterial administration of geranylgeranylacetone."

Related Drugs and Biologics

1.	HSP72 Heat-Shock Proteins
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Diclofenac (SR 38)
4.	rebamipide
5.	clopidogrel (Plavix)
6.	irsogladine
7.	Protein Kinase C
8.	Bleomycin (Blenoxane)
9.	NF-kappa B (NF-kB)
10.	Thioredoxins

Related Therapies and Procedures

1.	Oral Administration
2.	Hepatectomy
3.	Intraperitoneal Injections
4.	Induced Hyperthermia (Thermotherapy)