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DNP-Ficoll
thymus-independent antigen; 36 DNP residues per 400,000 MW
Also Known As:
2,4-DNP-Ficoll; 2,4-dinitrophenyl-Ficoll
Networked:
11
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Polysaccharides: 15383
Ficoll: 348
DNP-Ficoll: 11
Related Diseases
1.
Infections
08/01/1978 - "
Spleen cells harvested later in the infection (day 6 onwards) suppress the antibody response of normal spleen cells to both SRBC and DNP-Ficoll.
"
08/01/1978 - "
Spleen cells taken from mice soon after infection with Trypanosoma brucei S 42 enhance the primary in vitro antibody response of normal spleen cells to sheep red blood cells (SRBC), but do not affect their response to DNP-Ficoll.
"
07/01/1978 - "
Infection alone induced antibody reactive with DNP equivalent to that observed after immunization with DNP--Ficoll.
"
04/01/1983 - "
During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen.
"
10/01/1981 - "
Anti-DNP responses to DNP-Ficoll, a T-independent antigen, were suppressed by infection, but the suppressive effect was weaker than that on the responses to SRBC.
"
2.
Systemic Scleroderma (Systemic Sclerosis)
03/01/1990 - "
Cellular and humoral immune responses were assessed in 24 patients with systemic sclerosis and matched controls by immunization with a thymus dependent (TD) antigen, keyhole limpet hemocyanin (KLH), a and thymus independent (TI) antigen, dinitrophenylated Ficoll (DNP-Ficoll).
"
3.
Neoplasms (Cancer)
07/01/1981 - "
They also identify a provocative but unexplained association between positive IgM memory responses to DNP-Ficoll in SJL/J, AKR/J, and C58/J mice and a propensity to develop lymphoreticular neoplasia.
"
4.
Lymphoma (Lymphomas)
01/01/1986 - "
If the cell line lymphocytes are cultured with the antigen DNP-Ficoll without the presence of T cell factors or filler cells they do not produce an immune response above background, but the addition of supernatant from EL4 lymphoma and irradiated normal spleen filler cells results in a 7- to 10-fold increase in plaque-forming cells.
"
5.
Delayed Hypersensitivity (Hypersensitivity, Type IV)
01/01/1982 - "
The effects of the intravenous injection of DNP-Ficoll on delayed hypersensitivity reactions to bovine gamma globulins (BGG) and anaphylactic reactions to the hapten induced by immunization with DNP-BGG in Freund's adjuvant were studied in guinea pigs.
"
01/01/1982 - "
Animals treated with DNP-Ficoll exhibited stronger delayed hypersensitivity to BGG and lower anaphylactic reactions to the hapten than control animals treated with saline, Ficoll alone or with an unrelated protein antigen.
"
Related Drugs and Biologics
1.
Antigens
2.
Immunoglobulin M (IgM)
3.
Ficoll
4.
TCF Transcription Factors
5.
Proteins (Proteins, Gene)
6.
Peptidoglycan (Murein)
7.
Haptens
8.
gamma-Globulins (gamma-Globulin)
9.
Freund's Adjuvant
10.
Diazinon (Dimpylate)
Related Therapies and Procedures
1.
Intravenous Injections