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2-nitro-7-methoxynaphtho(2-1b)furan
structure given in first source
Also Known As:
7-methoxy-2-nitronaphtho(2,1-b)furan; R 7000; R-7000; Naphtho(2,1-b)furan, 7-methoxy-2-nitro-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitro Compounds: 66
Nitrofurans: 69
2-nitro-7-methoxynaphtho(2-1b)furan: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Furans: 85
Nitrofurans: 69
2-nitro-7-methoxynaphtho(2-1b)furan: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1985 - "
The number of tumor-bearing animals and the time between the first injection and the tumor appearance were closely related to the dose of R 7000 injected.
"
01/01/1985 - "
In those to whom R 7000 was administered tumors began to appear at the site of the injection after the third month.
"
01/01/1985 - "
In animals which did not receive R 7000, no malignant tumor was observed.
"
09/01/1986 - "
R 7000 is a weak carcinogen at the concentration employed here, when compared to some nitrosamines used in the development of forestomach cancer in rodents.
"
2.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/01/1986 - "
Subcutaneous injections of 7-methoxy 2-nitro naphtho [2,1-b] furan (R 7000) in C3H mice induce subcutaneous fibrosarcomas at the site of injection and squamous cell carcinomas of the stomach.
"
09/01/1986 - "
7-methoxy-2-nitro-naphtho[2,1-b] furan (R 7000), known as a very potent mutagen and a very active in vivo carcinogen was employed here to develop squamous cell carcinoma in the rat.
"
3.
Sarcoma (Soft Tissue Sarcoma)
01/01/1985 - "
Induction of sarcomas in rats by subcutaneous injection of 7-methoxy-2-nitro-naphtho[2,1-b]furan (R 7000).
"
4.
Fibrosarcoma
01/01/1986 - "
Subcutaneous injections of 7-methoxy 2-nitro naphtho [2,1-b] furan (R 7000) in C3H mice induce subcutaneous fibrosarcomas at the site of injection and squamous cell carcinomas of the stomach.
"
Related Drugs and Biologics
1.
furan
2.
Nitrosamines
3.
Mutagens
4.
Carcinogens
Related Therapies and Procedures
1.
Subcutaneous Injections