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cancer procoagulant

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a Factor X-activating cysteine endopeptidase from extracts of human & animal tumors & cultures of malignant cells

Also Known As:

Xase; Xase complex; amnion-chorion procoagulant; cancer procoagulant A; fXase; factor IXa-factor VIIIa; factor X activator; factor X procoagulant; factor Xase; intrinsic fXase; intrinsic tenase; neoplasm procoagulant A; neoplastic procoagulant; tenase

Networked: 104 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Skrzydlewski, Zdzisław: 5 articles (10/2005 - 08/2003)
2.	Skrzydlewski, Z: 5 articles (01/2005 - 03/2000)
3.	Mielicki, Wojciech P: 4 articles (10/2015 - 06/2008)
4.	Snarska, Jadwiga: 4 articles (03/2006 - 01/2003)
5.	Szajda, Sławomir Dariusz: 4 articles (10/2005 - 09/2004)
6.	Kozuszko, B: 4 articles (09/2001 - 03/2000)
7.	Zwierz, Krzysztof: 3 articles (03/2006 - 10/2005)
8.	Chabielska, Ewa: 3 articles (03/2006 - 06/2005)
9.	Darewicz, Barbara: 3 articles (10/2005 - 01/2005)
10.	Kudelski, Jacek: 3 articles (10/2005 - 01/2005)

Related Diseases

1.	Venous Thrombosis (Deep-Vein Thrombosis) 06/01/1997 - "We conclude that, in this study, prothrombinase rather than tenase inhibition was more effective in reducing venous thrombosis and that these effects can be achieved without disruption of extravascular hemostasis." 06/01/1997 - "In order to investigate the respective roles of prothrombinase and intrinsic tenase (IXa/VIIIa) in venous thrombosis, we compared the anti-thrombotic efficacy of inhibitors of these two coagulation complexes. " 03/03/2015 - "To explore the functions of inflammatory cytokine, tissue factor (TF) and cancer procoagulant (CP) in non-tumor deep venous thrombosis (NT-DVT). "
2.	Neoplasms (Cancer) 11/01/1989 - "The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. " 03/01/2012 - "We conclude that cancer procoagulant could potentially play a part in angiogenesis in cancer and vascular development during embryonic development." 01/01/2005 - "It was isolated from the rabbit's neoplasm type V2 Ca and then characterized and named as cancer procoagulant (CP). " 01/01/2003 - "The level of cancer procoagulant also increased in cancer tissues as well as in the serum. " 10/01/2000 - "[Expression of thrombogenic substances by neoplasms: TF and cancer procoagulant. "
3.	Hemorrhage 07/01/2015 - "These disrupt FVIII activity predominantly by preventing the formation of the tenase complex, leading to a serious bleeding disorder. " 09/01/2005 - "The physiological relevance of the tenase complex is evident in hemophilia A or B patients who present with bleeding disorders. " 03/06/2015 - "Furthermore, in vitro and in vivo studies suggested that fractions of 6-12 kDa may be very promising compounds as putative selective intrinsic Xase inhibitors with antithrombotic action, but without the consequences of major bleeding and factor XII activation. " 04/01/2012 - "This study was aimed to investigate the pro coagulation effects of hemocoagulase atrix and its effective components (batroxobin and factor X activator) on plasma of normal subjects and patients with bleeding disorders and their mechanisms. " 11/01/2006 - "FVIII is an important cofactor in the tenase coagulation factor complex, lack of FVIII causes severe bleeding, whereas high FVIII levels seem to be associated with venous and arterial thromboembolism. "
4.	Carcinoma (Carcinomatosis) 09/01/2004 - "[Cancer procoagulant activity in serum and neoplastic tissue in cases of cervical and uterine carcinoma]." 01/15/1990 - "The activity of cancer procoagulant (CP) during the development of Guérin epithelioma was studied in the blood of Wistar rats. " 01/15/1990 - "Cancer procoagulant in serum of rats during development of experimental epithelioma." 09/24/1985 - "Cancer procoagulant, a proteolytic procoagulant enzyme, has been purified from rabbit V2 carcinoma extracts by two procedures. " 03/01/1981 - "Cancer procoagulant was purified from a rabbit V2 carcinoma. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2001 - "Examination results point to the possibility of using the evaluation of cancer procoagulant activity in monitoring the course of treatment of patients with oesophagal, gastric and colorectal cancer." 01/01/2001 - "Cancer procoagulant activity in the blood serum of patients with oesophagal, gastric and colorectal cancer was evaluated before and after the tumour removal. " 01/01/2001 - "Cancer procoagulant as a marker in monitoring the therapy in cases of oesophageal, stomach and colorectal cancer." 03/01/2000 - "[Diagnostic significance of cancer procoagulant activity in colorectal cancer]." 09/01/2001 - "The cancer procoagulant activity has been evaluated in homogenates of esophagal, stomach and colorectal cancer tissues and in the blood serum of patients with these neoplasms's. "

Related Drugs and Biologics

1.	Thromboplastin (Tissue Factor)
2.	Factor X (Stuart Factor)
3.	Cysteine Proteases (Cysteine Protease)
4.	Batroxobin
5.	Malondialdehyde (Propanedial)
6.	Hormones
7.	Factor XII (Hageman Factor)
8.	Cathepsin D
9.	Thrombin
10.	cancer procoagulant

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Catheters