3-iodo-alpha-methyltyrosine

used for SPECT imaging of brain tumors; RN given refers to unlabeled cpd without stereoisomeric designation

Also Known As:

123I-IMT; 3-(123I)iodo-L-alpha-methyl tyrosine; 3-(125I)iodo-alpha-methyl-L-tyrosine; 3-iodo-alpha-methyltyrosine, (DL)-isomer; 3-iodo-alpha-methyltyrosine, (L)-isomer; 3-iodo-alpha-methyltyrosine, 123I-labeled; 3-iodo-alpha-methyltyrosine, 123I-labeled, (L)-isomer; 3-iodo-alpha-methyltyrosine, 131I-labeled, (D)-isomer; 3-iodo-alpha-methyltyrosine, 131I-labeled, (DL)-isomer; 3-iodo-alpha-methyltyrosine, 131I-labeled, (L)-isomer; L-3-(123)I-iodo alpha-methyltyrosine; L-3-iodo alpha-methyltyrosine

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Tyrosine: 10509
        Methyltyrosines
        3-iodo-alpha-methyltyrosine: 10

Experts

1.	Amthauer, Holger: 3 articles (04/2006 - 10/2004)
2.	Felix, Roland: 3 articles (04/2006 - 10/2004)
3.	Michel, Roger: 3 articles (04/2006 - 10/2004)
4.	Plotkin, Michail: 3 articles (04/2006 - 10/2004)
5.	Wurm, Reinhard: 3 articles (04/2006 - 10/2004)
6.	Bischoff, Annet: 2 articles (04/2006 - 02/2006)
7.	Denecke, Timm: 2 articles (04/2006 - 02/2006)
8.	Kuczer, David: 2 articles (04/2006 - 02/2006)
9.	Schlenger, Lorenz: 2 articles (04/2006 - 02/2006)
10.	Wust, Peter: 2 articles (04/2006 - 10/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2011 - "A high uptake of 123I-IMT was detected in all tumor-bearing mice. " 02/01/2011 - "123I-IMT was injected to eight mice inoculated with subcutaneous or orthotopic pancreatic tumors. " 04/01/2000 - "The advantages of 123I-IMT in this respect decrease with increasing 201Tl uptake and with increasing malignancy." 09/01/1998 - "After 8 days of tumor growth, the animals simultaneously were injected with a mixture of either 123I-IMT and 3H-Met (n=5), 123I-OMIMT and 3H-Met (n=8) or 123I-IMT and 125I-OMIMT (n=9). " 10/01/2004 - "In conclusion, 123I-IMT SPECT yielded more favorable results compared to 1H-MRS at distinguishing recurrent and/or residual glioma from post-therapeutic changes and may be particularly valuable when the evaluation of tumor extent is necessary."
2.	Glioma (Gliomas) 10/01/2004 - "123I-IMT SPECT and 1H MR-spectroscopy at 3.0 T in the differential diagnosis of recurrent or residual gliomas: a comparative study." 07/01/1998 - "Clinical symptoms indicated this in 7/7 situations, MRI in 5/7, 123I-IMT SPECT in 1/2 and 201Tl SPECT in 1/1. These data suggest that 123I-IMT SPECT is a valuable addition to low grade glioma diagnostic and stress the need for a prospective study." 04/01/2007 - "123I-IMT SPECT for evaluation of the response to radiation therapy in high grade gliomas: a feasibility study." 10/01/2004 - "In conclusion, 123I-IMT SPECT yielded more favorable results compared to 1H-MRS at distinguishing recurrent and/or residual glioma from post-therapeutic changes and may be particularly valuable when the evaluation of tumor extent is necessary." 05/01/2000 - "All malignant tumours except one small metastasis and all meningiomas except one small, cystic and degenerated lesion showed significant 201Tl accumulation [Tl(15')>2.0]; 123I-IMT uptake was either absent or intermediate in non-malignant lesions except in two low-grade gliomas; the highest levels were observed in high-grade gliomas followed by metastases and lymphomas (mean IMT: 2.7 vs. 2.1 vs. 1.8), with metastases showing a high variability in 123I-IMT uptake (range: 0.8-3.6). "
3.	Head and Neck Neoplasms (Head and Neck Cancer) 04/01/2006 - "Diagnostic value of 123I-IMT SPECT in the follow-up of head and neck cancer." 02/01/2006 - "Combined SPECT/CT imaging using 123I-IMT in the detection of recurrent or persistent head and neck cancer."
4.	Pancreatitis 02/01/2011 - "Since amino acids play a minor role in the metabolism of inflammatory cells, the potential for application of 123I-IMT to distinguish pancreatic tumor from inflammatory pancreatitis warrants further investigation."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2011 - "Our mouse model could show a high 123I-IMT uptake in pancreatic cancer. "

Related Drugs and Biologics

1.	Amino Acids

Related Therapies and Procedures

1.	Radiotherapy