St 587

clonidine derivative which is selective alpha(1)-adrenoceptor stimulator with lipophilic properties; structure in first source

Also Known As:

2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine; ST-587; 1H-Imidazol-2-amine, N-(2-chloro-5-(trifluoromethyl)phenyl)-4,5-dihydro-, mononitrate

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Borycz, Jolanta: 1 article (07/2002)
2.	Chojnacka-Wójcik, Ewa: 1 article (07/2002)
3.	Paluchowska, Maria H: 1 article (07/2002)
4.	Wesołowska, Anna: 1 article (07/2002)

1.	Tachycardia (Tachyarrhythmias) 08/27/1982 - "St 587 inhibited the tachycardia elicited by sympathetic stimulation in pithed rats. " 01/01/1985 - "At peripheral presynaptic sites St 587 (1 mg/kg i.v.) significantly antagonized the inhibitory effect of B-HT 920 (3-30 micrograms/kg i.v.) on electrically induced tachycardia in pithed rats. "
2.	Hypothermia 07/01/2002 - "The alpha1-adrenoceptor agonist St 587, which reduced the hypothermic effect of prazosin, inhibited the decrease in body temperature evoked by NAN-190 at the higher dose and by MP245 at both the doses used, but did not affect the MM77-induced hypothermia in mice. "
3.	Catalepsy 01/08/1985 - "induced catalepsy which was antagonized by St 587 in a dose-dependent manner (ED50 = 2.7 mg/kg i.p.). "
4.	Bradycardia 01/08/1985 - "As a positive control the alpha 2-adrenoceptor agonist B-HT 920 which is equipotent to St 587 with respect to peripheral vasopressor effects in rats was injected with 10 micrograms/kg intracisternally and facilitated the reflex bradycardia. "
5.	Hypoxia (Hypoxemia) 05/01/1995 - "Because St-587 but not PE constriction was dependent on VOC activation, the sensitivity of alpha 2D- but not alpha 1D-constriction to acidosis and hypoxia appeared to be independent of reliance on VOCs. "

1.	talipexole
2.	Prazosin (Minipress)
3.	1- (2- methoxyphenyl)- 4- (4- (2- phthalimido)butyl)piperazine