picolinic acid (chromium picolinate)

iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206

Also Known As:

Networked: 249 relevant articles (15 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sahin, Kazim: 7 articles (01/2019 - 09/2007)
2.	Komorowski, James R: 6 articles (01/2019 - 09/2005)
3.	Tuzcu, Mehmet: 6 articles (01/2019 - 09/2007)
4.	Sahin, Nurhan: 5 articles (01/2019 - 12/2009)
5.	Feng, Weiwei: 5 articles (03/2018 - 01/2015)
6.	Mao, Guanghua: 5 articles (03/2018 - 01/2015)
7.	Wu, Xiangyang: 5 articles (03/2018 - 01/2015)
8.	Yang, Liuqing: 5 articles (03/2018 - 01/2015)
9.	Zhao, Ting: 5 articles (03/2018 - 01/2015)
10.	Vincent, John B: 5 articles (07/2008 - 01/2003)

Related Diseases

1.	Insulin Resistance 09/07/2013 - "The aim of the current study was to test the safety and efficacy of chromium picolinate for HIV- associated insulin resistance. " 02/01/2008 - "The objective was to study the efficacy and safety of chromium picolinate as a treatment of insulin resistance in subjects infected with HIV. " 06/01/2023 - "Nano-chromium picolinate and heat stress enhance insulin sensitivity in cross-bred sheep." 02/01/2008 - "Chromium picolinate for insulin resistance in subjects with HIV disease: a pilot study." 08/01/2006 - "The agency concluded that the relationship between chromium picolinate intake and insulin resistance is highly uncertain."
2.	Taste Disorders (Taste Disorder) 07/01/1995 - "[Therapeutic efficacy of zinc picolinate in patients with taste disorders]." 01/01/2002 - "Double-blind, placebo-controlled trial of zinc picolinate for taste disorders." 07/01/1995 - "4. We conclude that the administration of zinc picolinate is effective for patients with zinc-deficient and idiopathic taste disorders." 07/01/1995 - "We studied the therapeutic efficacy of zinc picolinate in patients with zinc-deficient and idiopathic taste disorders. " 01/01/2002 - "A total of 73 patients with an idiopathic zinc-deficiency taste disorder completed a double-blind, placebo-controlled trial of the efficacy of zinc picolinate. "
3.	Type 2 Diabetes Mellitus (MODY) 10/01/2015 - "This study evaluated the effect of chromium picolinate (CrPic) supplementation in patients with type 2 diabetes mellitus (T2DM). " 10/01/1997 - "In a recent study, Chinese subjects with NIDDM were divided into three groups of 60 subjects and supplemented with placebo, 100 or 500 micrograms of Cr as chromium picolinate 2 times per day for 4 months. " 04/01/2014 - "Chromium picolinate (CrPic), which is used as a nutritional supplement and to treat type 2 diabetes, has gained much attention because of its cytotoxicity. " 01/01/2011 - "Chromium Picolinate for the Prevention of Type 2 Diabetes." 12/01/2009 - "Chromium picolinate (CrPic) has been discovered as a supplemental or alternative medication for type 2 diabetes, but its mechanism of action is not well understood. "
4.	Overweight 11/29/2013 - "Chromium picolinate supplementation for overweight or obese adults." 01/01/2021 - "Gdue is a nutraceutical obtained from the association of two marine algae, Ascophyllum nodosum and Fucus vesiculosus, in addition to chromium picolinate, which could be useful for the treatment of dysglycemia, overweight, and the other components of the metabolic syndrome. " 03/01/2010 - "This trial assesses the effects of chromium picolinate supplementation, alone and combined with nutritional education, on weight loss in apparently healthy overweight adults. " 03/01/2010 - "Supplementation of 1000 microg of chromium picolinate alone, and in combination with nutritional education, did not affect weight loss in this population of overweight adults. " 07/01/2013 - "Twenty-four overweight adults with BED were enrolled in a 6-month double-blind placebo-controlled trial and randomly assigned to receive either 1000mcg chromium/day ("high dose"; n=8) or 600mcg chromium/day ("moderate dose"; n=9) as chromium picolinate or placebo (n=7). "
5.	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/01/2021 - "Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients." 04/01/2009 - "Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults." 01/01/2021 - "Gdue is a nutraceutical obtained from the association of two marine algae, Ascophyllum nodosum and Fucus vesiculosus, in addition to chromium picolinate, which could be useful for the treatment of dysglycemia, overweight, and the other components of the metabolic syndrome. " 12/08/2017 - "This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III) trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs) and extracellular microvesicles (MVs) in equine metabolic syndrome-affected horses. " 04/01/2009 - "The objective of this study was to determine the effects of chromium picolinate (CrPic) on glucose metabolism in patients with metabolic syndrome. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Chromium
3.	Zinc
4.	Insulin (Novolin)
5.	Biotin (Vitamin H)
6.	Serotonin (5 Hydroxytryptamine)
7.	Insulin Receptor
8.	Atorvastatin (Lipitor)
9.	Streptozocin (Streptozotocin)
10.	Glycated Hemoglobin (Glycosylated Hemoglobin)

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Caloric Restriction
4.	Drug Therapy (Chemotherapy)
5.	Fat-Restricted Diet (Diet, Fat Restricted)