picolinic acid (chromium picolinate)

iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206

Also Known As:

Networked: 145 relevant articles (6 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Vincent, John B: 5 articles (07/2008 - 01/2003)
2.	Mao, Guanghua: 4 articles (11/2015 - 01/2015)
3.	Wu, Xiangyang: 4 articles (11/2015 - 01/2015)
4.	Zhao, Ting: 4 articles (11/2015 - 01/2015)
5.	Feng, Weiwei: 4 articles (11/2015 - 01/2015)
6.	Yang, Liuqing: 4 articles (11/2015 - 01/2015)
7.	Sahin, Kazim: 4 articles (12/2013 - 06/2008)
8.	Wang, Wei: 3 articles (11/2015 - 01/2015)
9.	Wu, Huiyu: 3 articles (11/2015 - 01/2015)
10.	Li, Fang: 3 articles (11/2015 - 01/2015)

Related Diseases

1.	Taste Disorders (Taste Disorder) 07/01/1995 - "[Therapeutic efficacy of zinc picolinate in patients with taste disorders]." 01/01/2002 - "Double-blind, placebo-controlled trial of zinc picolinate for taste disorders." 07/01/1995 - "4. We conclude that the administration of zinc picolinate is effective for patients with zinc-deficient and idiopathic taste disorders." 07/01/1995 - "We studied the therapeutic efficacy of zinc picolinate in patients with zinc-deficient and idiopathic taste disorders. " 01/01/2002 - "A total of 73 patients with an idiopathic zinc-deficiency taste disorder completed a double-blind, placebo-controlled trial of the efficacy of zinc picolinate. "
2.	Weight Loss (Weight Reduction) 03/01/2010 - "A pilot study of chromium picolinate for weight loss." 07/01/2007 - "Chromium picolinate (CrPic) is a synthetic nutritional supplement primarily used for weight loss and muscle building. " 01/01/2005 - "Chromium picolinate monohydrate (CPM) is a synthetic compound heavily marketed to consumers in the United States for use as a dietary supplement for muscle building and weight loss. " 01/01/2003 - "The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent." 04/01/1998 - "She had ingested chromium picolinate 1200-2400 microg/d for the previous 4-5 months to enhance weight loss. "
3.	Acne Vulgaris 03/01/2007 - "Results from this study suggest that 10% picolinic acid gel applied twice daily may be safe and effective in the treatment of mild to moderate acne vulgaris." 03/01/2007 - "To determine the safety and efficacy of picolinic acid, a novel zinc finger therapy, in the treatment of mild to moderate acne vulgaris. " 03/01/2007 - "A pilot study of the safety and efficacy of picolinic acid gel in the treatment of acne vulgaris." 03/01/2007 - "Twenty subjects with mild to moderate acne vulgaris were treated at our centre during an open-label study with 10% picolinic acid gel (PCL-016) twice daily to the face over 12 weeks. " 06/01/2013 - "The borinic picolinate, AN0128, is an antibacterial compound with anti-inflammatory activity that has been studied in clinical trials for acne and the treatment of mild to moderate atopic dermatitis. "
4.	Weight Gain 08/01/2005 - "3. Supplementing the diet of heat-stressed quails with chromium picolinate improved live weight gain, feed intake, feed efficiency and carcase traits. " 10/01/2008 - "Chromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown. " 08/01/1997 - "Chromium picolinate supplementation resulted in significant weight gain in this population, while exercise training combined with chromium nicotinate supplementation resulted in significant weight loss and lowered the insulin response to an oral glucose load. "
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 07/01/2006 - "This suggests that chromium picolinate, an over-the-counter dietary product, may be useful as an insulin sensitizer in the treatment of polycystic ovary syndrome." 07/01/2006 - "Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome." 12/01/2005 - "In women with polycystic ovary syndrome, chromium picolinate (200 microg/d) improves glucose tolerance compared with placebo but does not improve ovulatory frequency or hormonal parameters. " 07/01/2006 - "Trivalent chromium (1000 microg), as chromium picolinate, given without change in diet or activity level, caused a 38% mean improvement in glucose disposal rate in five obese subjects with polycystic ovary syndrome who were tested with a euglycemic hyperinsulinemic clamp technique. "

Related Drugs and Biologics

1.	Chromium
2.	Glucose (Dextrose)
3.	Zinc
4.	picolinic acid (chromium picolinate)
5.	Insulin (Novolin)
6.	Niacin (Nicotinic Acid)
7.	Blood Glucose (Blood Sugar)
8.	Biotin (Vitamin H)
9.	Iron
10.	LDL Cholesterol

Related Therapies and Procedures

1.	Caloric Restriction
2.	Drug Therapy (Chemotherapy)
3.	Fat-Restricted Diet (Diet, Fat Restricted)
4.	Resistance Training
5.	Photochemotherapy (Photodynamic Therapy)