filaggrin

12/01/2011 - "Knowledge of the existence of filaggrin (FLG) gene mutations might be helpful for a subclassification of patients with atopic dermatitis (AD) which can be used to introduce individualized treatments. "
02/01/2014 - "This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). "
01/01/2014 - "Our study indicates that the filaggrin gene mutation c.3321delA is associated with clinical phenotypes of atopic dermatitis in the Chinese Han population, which might help us gain a better understanding on the pathogenesis of atopic dermatitis."
12/01/2013 - "The genetic basis is incompletely understood; however, recent studies have shown an association between loss-of-function variants of the filaggrin gene (FLG) and atopic dermatitis. "
10/01/2013 - "A familial study of filaggrin mutation in atopic dermatitis."

04/01/1989 - "These studies suggest that human skin filaggrin can be considered a marker of clinical remission of psoriasis."
06/01/2012 - "  Psoriasis was not associated with the R501X and 2282del4 filaggrin null genotypes in a general population study and in a meta-analysis on published studies."
06/01/2012 - "Also, to perform a meta-analysis including published studies that investigated the relation between filaggrin gene mutations R501X and 2282del4, respectively, and psoriasis vulgaris. "
06/01/2012 - "The filaggrin null genotypes R501X and 2282del4 seem not to be associated with psoriasis: results from general population study and meta-analysis."
04/01/1989 - "[Study of filaggrin in psoriasis]."

02/01/2011 - "Therefore, the findings of this study show that reduced filaggrin levels may influence innate immune responses via TLR stimuli and may contribute to the pathogenesis of inflammatory skin disease via TSLP expression."
06/20/2014 - "Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin."
05/01/2014 - "Individuals with wild-type filaggrin displayed both the most acidic and most alkaline values independent of concomitant skin disease; however, no statistical differences between the groups were found. "
02/01/2013 - "The multifunctional role of filaggrin in allergic skin disease."
09/01/2012 - "In this review, we have discussed the structure and function of filaggrin, basic genetics, type of mutations in filaggrin gene, and association of such mutations with different dermatoses."

03/01/2012 - "The natural history of individuals with the filaggrin null genotype is fairly good in the sense that they may not develop dermatitis at all, and if they do, they may experience complete remission."
03/01/2012 - "Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible."
03/01/2012 - "No studies have investigated whether individuals with the homozygous filaggrin null genotype always develop dermatitis. "
03/01/2015 - "Anatomical patterns of dermatitis in adult filaggrin mutation carriers."
01/01/2015 - "Morphological changes in the TJ were investigated in filaggrin knockout mice and mice with hapten-induced dermatitis using en face visualization of epidermal sheets, and functional changes in the TJ were assessed with an in vivo permeation assay using tracers of various sizes. "

11/01/2008 - "Furthermore, we suggest future studies of atopic hand eczema to analyse for the filaggrin mutations. "
01/01/2008 - "Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema. "
06/01/2015 - "Trans-cutaneous sensitization, particularly in those with eczema or filaggrin mutations, has been posited as a potential mechanism, as well as gut microbiota and genetics/epigenetics. "
03/01/2013 - "At 86% methylation level, filaggrin haploinsufficient individuals had a 5.48-fold increased risk of eczema when compared to those with wild type FLG genotype (P-value = 0.0008). "
03/01/2013 - "Loss-of-function variants within the filaggrin gene (FLG) are associated with a dysfunctional skin barrier that contributes to the development of eczema. "