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B 669 (B669)

structure in first source

Also Known As:

B669; B-669; 2-Phenazinamine, 3-(cyclohexylimino)-3,5-dihydro-N,5-diphenyl-

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - Clofazimine: 767
        B 669: 8

Experts

1.	Jooné, G K: 1 article (01/2001)
2.	O'Sullivan, J F: 1 article (01/2001)
3.	van Niekerk, E: 1 article (01/2001)
4.	van Rensburg, C E: 1 article (01/2001)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1993 - "Evaluation of the antineoplastic activities of the riminophenazine agents clofazimine and b669 in tumor-bearing rats and mice." 01/15/1993 - "The riminophenazine agents clofazimine and B669 inhibit the proliferation of cancer cell lines in vitro by phospholipase A2-mediated oxidative and nonoxidative mechanisms." 05/01/1994 - "The antiproliferative riminophenazine agents clofazimine and b669 promote lysophospholipid-mediated inhibition of na+, k+-adenosine triphosphatase-activity in cancer cell-lines in-vitro." 11/01/1993 - "The riminophenazine agents clofazimine and its analogue B669 displayed anti-tumor activity at 30 mg/kg/day in benzo[a]pyrene (BP) induced sarcomas of mice as well as dimethylbenz-anthracene (DMBA)-induced rat mammary tumors. "
2.	Lung Neoplasms (Lung Cancer) 09/30/1994 - "The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line." 09/30/1994 - "The potential of the riminophenazine agents clofazimine and B669, at therapeutically relevant concentrations, to reverse P-glycoprotein-mediated multidrug-resistance (MDR) in a human lung cancer cell line (H69/LX4) has been investigated in vitro. " 05/15/1998 - "The effects of the membrane-stabilizing agent, alpha-tocopherol (25 microg/ml), on the chemosensitizing interactions of cyclosporin A (5 microg/ml), verapamil (2 microg/ml), clofazimine (1 microg/ml), B669 (0.5 microg/ml) and GF120918 (0.015 microg/ml) with a P-glycoprotein-expressing human lung cancer cell line (H69/LX4) have been investigated in vitro. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1996 - "The sensitivity to clofazimine, B669 and eight standard anti-tumour chemotherapeutic agents of four intrinsically multidrug resistant (MDR) cell lines [three human hepatocellular carcinoma cell lines (HepG2, PLC and Mahlavu) and a human colorectal carcinoma cell line (CaCo2)] were compared with that of a human cervix epithelioid carcinoma cell line (HeLa). " 01/01/2001 - "The effects of nine new tetramethylpiperidine (TMP)-substituted phenazines on the growth of a human esophageal cancer cell line (WHCO3), two human hepatocellular carcinoma cell lines (PLC and HepG2) and three human colon cancer cell lines (CaCo2, COLO 320DM and HT29) were compared to those of clofazimine, B669 and five standard chemotherapeutic agents. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/15/1993 - "Clofazimine, a riminophenazine antimicrobial agent, and its analogue B669 were investigated for their effects on FaDu cells, a human squamous carcinoma cell line. " 05/01/1994 - "The effects of the anti-proliferative, phospholipase A(2) (PLA(2))-activating riminophenazine agents, clofazimine and B669, on the Na+, K+-adenosine triphosphatase activity of the FaDu human pharynx squamous carcinoma cell line have been investigated in vitro. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/1996 - "The sensitivity to clofazimine, B669 and eight standard anti-tumour chemotherapeutic agents of four intrinsically multidrug resistant (MDR) cell lines [three human hepatocellular carcinoma cell lines (HepG2, PLC and Mahlavu) and a human colorectal carcinoma cell line (CaCo2)] were compared with that of a human cervix epithelioid carcinoma cell line (HeLa). "

Related Drugs and Biologics

1.	Clofazimine (Lamprene)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Thymidine Monophosphate (TMP)
4.	Phospholipases (Phospholipase)
5.	Phenazines
6.	alpha-Tocopherol
7.	Cyclosporine (Ciclosporin)
8.	Verapamil (Calan)
9.	Lysophospholipids
10.	Excipients (Suspending Agents)