bacterial lysate

bacterial lysate used in therapy of chronic bronchitis; each capsule contains 7mg lysate of Haemophilus influenza, Diplococcus pneumonia, Klebsiella pneumonia & ozaenae, Staph. aureus, Strep. pyogenes & viridans, Neisseria caterrhalis

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Networked: 138 relevant articles (27 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Melioli, Giovanni: 5 articles (08/2015 - 07/2011)
2.	Canonica, Giorgio Walter: 4 articles (08/2015 - 01/2013)
3.	Braido, Fulvio: 4 articles (08/2015 - 01/2013)
4.	Berber, A: 4 articles (01/2003 - 06/2000)
5.	Cazzola, Mario: 3 articles (08/2015 - 04/2009)
6.	Garelli, Valentina: 3 articles (12/2014 - 01/2013)
7.	Evans, Scott E: 3 articles (05/2011 - 01/2009)
8.	Dickey, Burton F: 3 articles (05/2011 - 01/2009)
9.	Tuvim, Michael J: 3 articles (05/2011 - 01/2009)
10.	He, Fan: 2 articles (07/2014 - 12/2012)

Related Diseases

1.	Respiratory Tract Infections (Respiratory Tract Infection) 05/01/2002 - "This study evaluated the safety and efficacy of the immunostimulatory agent OM-85 BV in 112 male car-factory workers who were highly susceptible to acute respiratory tract infections (ARTIs), each having experienced > or = 4 ARTIs during 1999. " 01/01/1997 - "In conclusion, Broncho-Vaxom appears to be a practical, safe option for lowering the incidence of respiratory tract infections in susceptible children." 09/01/2010 - "The bacterial extract OM-85 BV has been shown to provide protection against recurrent respiratory infections. " 07/01/2001 - "Efficacy of a polyvalent bacterial lysate in children with recurrent respiratory tract infections." 06/01/2001 - "Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months."
2.	Infection 01/01/1997 - "During the 6-month follow-up period, patients treated with Broncho-Vaxom showed a significant reduction in the average number of infections (2.25 +/- 0.58 vs 4.68 +/- 0.94, p < 0.05); they were ill a lesser number of days (11.8 +/- 3.67 vs 28.06 +/- 6.72, p < 0.05), were exposed to fewer antibacterial treatments (1.1 +/- 0.76 vs 2.52 +/- 0.85, p < 0.05), required less additional treatment with conventional drugs (2.17 +/- 0.59 vs 4.39 +/- 0.88, p < 0.05), and spent fewer days under treatment (14.27 +/- 7.27 vs 30 +/- 6.49, p < 0.05). " 01/01/1992 - "These results indicate the efficacy of oral immunostimulation with the bacterial extract OM-85 BV in all age groups and demonstrate its protective effect against recurrent airway infections." 01/01/2004 - "The aim of the present study was to evaluate the efficacy of the immunostimulating therapy with a new vaccine Ismigen in preventing recurrent infections of the upper respiratory tract in subjects belonging to a community of cloistered nuns. " 07/01/2006 - "The aim of the present study is to investigate in humans the mechanism by which the oral vaccine Polyvalent Mechanical Bacterial Lysate (PMBL) can rapidly mobilize specific immune response and evaluate the efficacy of its immunostimulating activity in preventing recurrent infections of the upper respiratory tract (URTIs) in a group of patients with a medical history of URTI recurrence. " 01/01/2014 - "In these conditions, the positive results observed demonstrated that this bacterial lysate has maintained its capacity of reducing the days with infections in patients with RRTI, also in association to the concomitant therapies available nowadays."
3.	Chronic Bronchitis 01/01/1989 - "The authors report on a clinical study conducted in 1985/86 for evaluating the efficacy of Broncho-Vaxom in children with chronic bronchitis. " 06/23/1984 - "The efficacy of Broncho-Vaxom has been evaluated by a multicentric working group of physicians in 75 patients with chronic bronchitis using a randomized double-blind trial. " 01/01/1993 - "Three hundred fifty six patients aged 65 years or more (mean age 81.8 years) who were suffering from chronic bronchitis were included in a double-blind trial against placebo to assess the preventative effect of OM-85 BV against acute exacerbations of chronic bronchitis. " 06/01/2000 - "The bacterial extract OM-85 BV has shown some protective effect for ARTIs in preschool children and a reduction in exacerbations of chronic bronchitis in adults. " 01/01/1993 - "[Preventive effect of an immunomodulator, OM-85 BV, on acute exacerbations of chronic bronchitis in elderly patients. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2015 - "Further larger-scale trials must be conducted to validate our findings and the efficacy of OM-85 BV in COPD patients. " 10/01/2015 - "This study aimed to identify the effects of OM-85 BV in patients with chronic obstructive pulmonary disease (COPD). " 01/01/2013 - "Aim of this review is to summarize the main clinical studies on the effect of the bacterial lysate OM-85 in treating RTIs in susceptible subjects - namely children and chronic obstructive pulmonary disease (COPD)-affected adults. " 10/01/2015 - "Current evidence supporting the benefits of OM-85 BV to COPD patients is inadequate. " 10/01/2015 - "Effects of OM-85 BV in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis."
5.	Rhinitis 01/01/2007 - "The aim of the present trial is to evaluate the efficacy of the treatment with an immunostimulating vaccine consisting of a polyvalent mechanical bacterial lysate (PMBL) in the prophylaxis of allergic rhinitis and subsequently to analyze its in vivo effects on immune responses. " 03/01/2014 - "A bacterial extract of OM-85 Broncho-Vaxom prevents allergic rhinitis in mice." 01/01/2007 - "Improvement of clinical response in allergic rhinitis patients treated with an oral immunostimulating bacterial lysate: in vivo immunological effects." 11/01/2015 - "Cost Consequence Of Preventive Treatment With Om 85 Bacterial Lysate Compared To The Same Patients Without Om 85 The Previous Year In Allergic Rhinitis, Asthma And Copd In Argentina."

Related Drugs and Biologics

1.	bacterial lysate
2.	LW 50020
3.	Interleukin-10 (Interleukin 10)
4.	HLA-B27 Antigen (HLA B27 Antigen)
5.	Immunoglobulin G (IgG)
6.	Immunoglobulin A (IgA)
7.	Immunoglobulin M (IgM)
8.	Antibodies
9.	Secretory Immunoglobulin A (SIgA)
10.	Penicillins (Penicillin)

Related Therapies and Procedures

1.	Oral Administration
2.	Immunomodulation
3.	Intraperitoneal Injections
4.	Immunotherapy
5.	Tonsillectomy