isocorydine

from root tubers of Stephania Kwangsiensis H.S. Lo; RN given refers to (+-)-isomer; structure in Merck Index, 9th ed, #5017

Also Known As:

isocorydine hydrochloride, (S)-isomer; isocorydine, (R)-isomer; isocorydine, (S)-isomer; 4H-dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (+-)

Networked: 11 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - Aporphines: 10
      - isocorydine: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        Aporphines: 10
        isocorydine: 11
  - 4 or More Rings Heterocyclic Compounds
    - Aporphines: 10
      - isocorydine: 11

Experts

1.	Ge, Chao: 5 articles (02/2017 - 01/2012)
2.	Li, Jinjun: 5 articles (02/2017 - 01/2012)
3.	Yao, Ming: 5 articles (02/2017 - 01/2012)
4.	Zhao, Fangyu: 4 articles (02/2017 - 01/2012)
5.	Zhang, Lixing: 4 articles (05/2016 - 01/2012)
6.	Liu, Junxi: 3 articles (01/2021 - 09/2015)
7.	Li, Hong: 3 articles (02/2017 - 09/2015)
8.	Tian, Hua: 3 articles (02/2017 - 09/2015)
9.	Wang, Tingpu: 3 articles (05/2016 - 01/2012)
10.	Ye, Long-Yun: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Acute Lung Injury 02/27/2023 - "Isocorydine Ameliorates IL-6 Expression in Bone Marrow-Derived Macrophages and Acute Lung Injury Induced by Lipopolysaccharide."
2.	Hepatocellular Carcinoma (Hepatoma) 09/22/2015 - "In our previous studies, we reported that CD133(+) cancer stem cells (CSCs) were chemoresistant in hepatocellular carcinoma (HCC) and that isocorydine treatment decreased the percentage of CD133(+) CSCs. " 02/27/2017 - "Derivate Isocorydine (d-ICD) Suppresses Migration and Invasion of Hepatocellular Carcinoma Cell by Downregulating ITGA1 Expression." 05/01/2016 - "Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis." 09/22/2015 - "An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma." 09/25/2012 - "Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma."
3.	Neoplasms (Cancer) 08/01/2017 - "The results showed that isocorydine and its analogs all have the growth inhibition for those cancer cell lines. " 05/01/2016 - "A novel derivate of isocorydine (d-ICD) could significantly improve its anticancer activity in tumors. " 01/01/2020 - "Isocorydine (ICD) is a typical natural aporphine alkaloid, and ICD and its derivatives inhibit the proliferation of many types of cancer cells in vitro. "
4.	Sepsis (Septicemia) 01/01/2022 - "Among them, isocorydine has a strong anti-sepsis effect, which is tightly related to its upregulation of VDR expression and inhibition of NFκB p65 translocation into the nucleus, leading to reduced pro-inflammatory cytokines release and protection for LPS-challenged mice." 01/01/2022 - "The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus."
5.	Spasm (Spasms) 02/27/2023 - "Isocorydine (ICD) is a type of isoquinoline alkaloid originating from Corydalis edulis, which has been used to relieve spasm, dilate blood vessels, and treat malaria as well as hypoxia in clinic. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Lipopolysaccharides
3.	Antineoplastic Agents (Antineoplastics)
4.	Alkaloids
5.	Calcitriol Receptors (Calcitriol Receptor)
6.	Cytokines
7.	Doxorubicin (Adriamycin)
8.	Gemcitabine
9.	aporphine
10.	isoquinoline