pipequaline

anticonflict & anticonvulsant quinoline derivative; structure given in first source

Also Known As:

2-phenyl-4-(2-(4-piperidinyl)ethyl)quinoline; PK 8165; PK-8165; Quinoline, 2-phenyl-4-(2-(4-piperidinyl)ethyl)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Lethargy 01/01/1988 - "Addition diazepam to pipequaline increased drowsiness and general lethargy, with a less marked effect occurring for the higher dose of pipequaline alone. "
2.	Seizures (Absence Seizure) 10/01/1984 - "PK 8165 potentiates (12.5 to 50 mg/kg i.p.) the antagonistic effect of DZ on M.E.S.-induced seizures and footshock-induced fighting in mice. "
3.	Myoclonus (Nocturnal Myoclonus) 12/01/1984 - "The quinolines, PK 8165, PK 9084 and CGS 8216 caused myoclonic jerks when combined with subconvulsant doses of Ro 5-3663 or picrotoxin; in combination with picrotoxin they also caused full tonic-clonic convulsions. "
4.	Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic) 12/01/1984 - "The quinolines, PK 8165, PK 9084 and CGS 8216 caused myoclonic jerks when combined with subconvulsant doses of Ro 5-3663 or picrotoxin; in combination with picrotoxin they also caused full tonic-clonic convulsions. "
5.	Ataxia (Dyssynergia) 01/01/1982 - "Benzodiazepines, PK 8165 and PK 9084 have anticonflictual properties but cause neither ataxia nor sedation even at doses 5 to 20 times greater than anticonflictual doses. "

1.	PK 9084
2.	Quinolines
3.	Picrotoxin
4.	Diazepam (Valium)
5.	Benzodiazepines
6.	2- phenylpyrazolo(4,3- c)quinolin- 3(5H)- one
7.	Ro 5-3663