squaric acid

RN given refers to parent cpd

Also Known As:

squaric acid, dipotassium salt; squaric acid, disilver (+1) salt; squaric acid, disodium salt; squaric acid, monopotassium salt; squaric acid, monopotassium salt monohydrate; squaric acid, nickel (+2), (1:1) salt dihydrate

Networked: 91 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclobutanes
        squaric acid: 91

Experts

1.	LaMotte, Robert H: 4 articles (09/2019 - 09/2014)
2.	Shimada, Steven G: 4 articles (09/2019 - 09/2014)
3.	Micali, G: 4 articles (02/2005 - 04/2000)
4.	Nasca, M R: 4 articles (02/2005 - 04/2000)
5.	Fu, Kai: 3 articles (01/2017 - 09/2014)
6.	Qu, Lintao: 3 articles (01/2017 - 09/2014)
7.	Zhao, Zhongqiu: 2 articles (05/2021 - 01/2020)
8.	Nie, Hong: 2 articles (09/2019 - 09/2014)
9.	Graciotti, Michele: 2 articles (01/2019 - 01/2018)
10.	Kandalaft, Lana E: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Alopecia Areata 08/01/2000 - "In this study we examined the effects of squaric acid dibutylester treatment on hair follicles and the associated leukocyte infiltrate in alopecia areata mice by light and transmission electron microscopic analysis. " 07/01/1999 - "Immunohistomorphometric studies revealed that treatment with squaric acid dibutylester increased the CD4+/CD8+ ratio from approximately 1:2 in untreated alopecia areata to 1:1 in treated alopecia areata. " 09/01/2015 - "Squaric acid sensitization is not required for response in the treatment of alopecia areata." 05/01/2015 - "This contribution reviews the history of the topical sensitizing agent squaric acid dibutylester and discusses the mechanism of action, the use in alopecia areata, and the efficacy and safety of this therapeutic agent." 05/01/2015 - "Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. "
2.	Warts (Wart) 09/01/2017 - "Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial." 03/01/2008 - "Here we present a case of successful treatment of recalcitrant warts with topical squaric acid in an immunosuppressed child." 03/01/2008 - "Successful treatment of recalcitrant warts with topical squaric acid in immunosuppressed child." 04/01/2000 - "Treatment of cutaneous warts with squaric acid dibutylester: a decade of experience." 01/01/2015 - "Examining the efficacy and safety of squaric acid therapy for treatment of recalcitrant warts in children."
3.	Alopecia (Baldness) 04/01/2010 - "His scalp alopecia responded to squaric acid dibutylester contact sensitization therapy. " 07/01/1999 - "In conclusion, alopecia areata-like hair loss in C3H/HeJ mice responded to treatment with the contact sensitizer squaric acid dibutylester analogous to human alopecia areata. " 06/01/2016 - "The mean values of percentage change in baseline severity of alopecia tool score for squaric acid dibutylester and diphenylcyclopropenone were 52.25 and 34.45, respectively. " 01/01/1987 - "The patients were subdivided into different groups depending on hair loss area, sex, pathogenesis, response to topical immune modulators (squaric acid dibutylester and diphencyprone) and age of onset of the disease. " 07/01/1999 - "Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice."
4.	Allergic Contact Dermatitis 01/01/2020 - "In this study, we investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of allergic contact dermatitis induced by squaric acid dibutylester. " 01/01/1993 - "Iatrogenic benign lymphoplasia induced by allergic contact dermatitis from squaric acid dibutylester: immunohistologic study of cellular infiltrates." 01/01/2018 - "Genetic and pharmacologic approaches were used to examine the role and underlying mechanisms of TRPV4 in mouse models of dry skin-associated chronic itch and spontaneous scratching associated with squaric acid dibutylester-induced allergic contact dermatitis. " 07/01/1999 - "In 12 C3H/HeJ mice with alopecia areata an allergic contact dermatitis was induced and elicited weekly on one side of the back by topical applications of squaric acid dibutylester. " 01/01/2017 - "We suggest that Cl- channels are likely key molecular candidates responsible for the CXCL10-evoked neuronal activation and itch-like behaviors in a murine model of allergic contact dermatitis induced by the antigen squaric acid dibutylester. "
5.	Neoplasms (Cancer) 01/01/2018 - "Vaccination in tumor-bearing mice showed that IFNα-differentiated DCs pulsed with squaric acid-treated lysates were the most potent at delaying tumor growth, improving animal survival. " 06/27/2023 - "Therefore, the present study suggests a novel ex vivo dendritic cell (DC) priming technique that utilizes (1) squaric acid (SqA)-mediated oxidation of source tumor cells to obtain antigenic TCLs with an increased immunogenic potential and (2) a coacervate (Coa) colloidal complex as an exogenous TCL carrier. " 01/01/2018 - "Conclusion: We identified squaric acid as a novel immunogenic treatment of tumor cells for cancer vaccines particularly efficient in prolonging animal survival when used in combination with IFNα-differentiated DCs. " 07/01/2013 - "A series of novel 3,4-diaryl squaric acid analogs 4a-r related to combretastatin A-4 (CA4) using squaric acid as the cis-restricted linker were prepared and studied for their anticancer activity against selected human cancer cell lines. " 01/01/2021 - "Squaric Acid-Based Radiopharmaceuticals for Tumor Imaging and Therapy."

Related Drugs and Biologics

1.	squaric acid dibutyl ester
2.	Allergens
3.	Immunologic Factors (Immunomodulators)
4.	diphenylcyclopropenone
5.	Dinitrochlorobenzene (DNCB)
6.	Antigens
7.	Anthralin (Dithranol)
8.	Genistein
9.	Interferon-alpha (Interferon Alfa)
10.	Thymopentin

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Cryotherapy (Therapy, Cold)
4.	Dye Lasers
5.	Injections