carbene

electrically neutral species H2C: and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons; carbene is the name of the parent hydride :CH2 ; hence, the name dichlorocarbene for :CCl2. However, names for acyclic and cyclic hydrocarbons containing one or more divalent carbon atoms are derived from the name of the corresponding all-4-hydrocarbon using the suffix -ylidene; methylene carbene also available

Also Known As:

Networked: 119 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ott, Ingo: 8 articles (03/2020 - 09/2014)
2.	Che, Chi-Ming: 6 articles (01/2021 - 06/2010)
3.	Bellemin-Laponnaz, Stéphane: 5 articles (10/2020 - 12/2014)
4.	Youngs, Wiley J: 5 articles (01/2012 - 01/2008)
5.	Lok, Chun-Nam: 4 articles (01/2021 - 06/2014)
6.	Casini, Angela: 4 articles (12/2020 - 08/2013)
7.	Dahm, Georges: 4 articles (10/2020 - 01/2016)
8.	Cannon, Carolyn L: 4 articles (01/2012 - 08/2009)
9.	Panzner, Matthew J: 4 articles (01/2012 - 01/2008)
10.	Hindi, Khadijah M: 4 articles (09/2009 - 01/2008)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2020 - "In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe2 and NHC*-Au-S-GLUC against advanced prostate cancer PC3." 12/12/2022 - "Herein, we have completed a thorough study to better understand the effect within the cell of the already published ruthenium(II)-N-heterocyclic carbene metallodendrimer (G2Ru) that was able to drastically reduce HIF-1α stabilization and exhibited antiproliferative capability against androgen-sensitive (LNCaP) and androgen-resistant prostate cancer cells (LNFLU) in vitro. " 06/20/2017 - "A homogeneous carbene-based palladium catalyst was conjugated to a cell-penetrating peptide, allowing intracellular delivery of catalytically active Pd complexes that demonstrated bioorthogonal activation of a profluorophore within prostate cancer cells." 01/01/2019 - "The exchange of phosphane by N-heterocyclic carbene ligands to improve or modulate their pharmacological profile afforded bimetallic complexes effective against prostate cancer, but less effective against renal cancer in vitro. " 01/01/2019 - "Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines."
2.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 09/05/2019 - "The development of chemically addressable N-heterocyclic carbene (NHC) based self-assembled monolayers (SAMs) requires in-depth understanding of the influence of NHC's anchoring geometry on its chemical functionality. " 05/28/2019 - "The results from this work show interesting possibilities for the preparation of adsorbed monolayers with chemical interaction to reactive metals, with some similarities to carbene-based SAMs." 11/15/2017 - "As an alternative, recent studies employing N-heterocyclic carbene (NHC) self-assembled monolayers (SAMs) deposited on gold have shown significant promise in this area. " 04/28/2016 - "In this work, we have functionalized tiny diamondoids using NHCs in order to prepare highly stable carbene-mediated diamondoid SAMs on metal substrates. " 04/28/2016 - "N-heterocyclic carbenes (NHC)s are emerging as an alternative class of molecules to thiol-based self-assembled monolayers (SAMs), making carbene-based SAMs much more stable under harsh environmental conditions. "
3.	Melanoma (Melanoma, Malignant) 03/13/2014 - "Gold (I) N-heterocyclic carbene complex inhibits mouse melanoma growth by p53 upregulation." 06/19/2023 - "Human malignant melanoma cells from lymph node metastatic site (MeWo) were selected for testing several synthesized and purified silver(I) and gold(I) complexes stabilized by unsymmetrically substituted N-heterocyclic carbene (NHC) ligands, called L20 (N-methyl, N'-[2-hydroxy ethylphenyl]imidazol-2-ylide) and M1 (4,5-dichloro, N-methyl, N'-[2-hydroxy ethylphenyl]imidazol-2-ylide), having halogenide (Cl- or I-) or aminoacyl (Gly=N-(tert-Butoxycarbonyl)glycinate or Phe=(S)-N-(tert-Butoxycarbonyl)phenylalaninate) counterion. " 03/13/2014 - "The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-κB, VEGF and MMP-9)." 10/22/2020 - "We describe here the evaluation of the cytotoxic efficacy of two platinum (II) complexes bearing an N-heterocyclic carbene (NHC) ligand, a pyridine ligand and bromide or iodide ligands on a panel of human metastatic cutaneous melanoma cell lines representing different genetic subsets including BRAF-inhibitor-resistant cell lines, namely A375, SK-MEL-28, MeWo, HMCB, A375-R, SK-MEL-5-R and 501MEL-R. "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 08/01/2009 - "The development of a compound composed of silver coupled to a methylated caffeine carrier (silver carbene complex 1 [SCC1]) that demonstrated in vitro efficacy against bacteria, including drug-resistant organisms, isolated from patients with respiratory tract infections was described previously. "
5.	Kidney Neoplasms (Kidney Cancer) 01/01/2019 - "The exchange of phosphane by N-heterocyclic carbene ligands to improve or modulate their pharmacological profile afforded bimetallic complexes effective against prostate cancer, but less effective against renal cancer in vitro. "

Related Drugs and Biologics

1.	Ligands
2.	Gold
3.	Silver
4.	Caffeine (No Doz)
5.	Platinum
6.	phosphine (phosphane)
7.	pyridine
8.	Iodides
9.	Bromides
10.	Ruthenium

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Electrodes (Electrode)