HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

nidogen (entactin)

basal lamina-associated sulfated glycoprotein; GenBank AJ224450 (rat); RefSeq NM_010917 (mouse); NM_002508 (human)

Also Known As:

entactin; NID1 protein, human; Nid protein, rat; Nid1 protein, mouse; Nid1 protein, rat; enactin protein, human; entactin protein, rat; entactin-1 protein, mouse; nidogen 1; nidogen 1 protein, human; nidogen 1 protein, mouse; nidogen protein, rat; nidogen-1

Networked: 129 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Glycoproteins: 18176
    - Membrane Glycoproteins: 1848
      - nidogen: 129
  - Membrane Proteins: 5300
    - Membrane Glycoproteins: 1848
      - nidogen: 129

Experts

1.	Nischt, Roswitha: 5 articles (11/2014 - 12/2006)
2.	Smyth, Neil: 3 articles (01/2014 - 12/2006)
3.	Miosge, Nicolai: 3 articles (04/2012 - 05/2008)
4.	Lee, Hyun Kyoung: 3 articles (08/2009 - 04/2006)
5.	Seo, In Ae: 3 articles (08/2009 - 04/2006)
6.	Park, Hwan Tae: 3 articles (08/2009 - 04/2006)
7.	Li, Lin: 2 articles (02/2015 - 03/2010)
8.	Paulsson, Mats: 2 articles (01/2014 - 12/2006)
9.	Bechtel, Manuela: 2 articles (04/2012 - 01/2010)
10.	Mokkapati, Sharada: 2 articles (04/2012 - 01/2010)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2013 - "Our studies also reveal that the cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. " 02/01/2015 - "The concentration of nidogen-1 in circulating plasma specimens of 265 ovarian serous cancer patients and 98 healthy individuals were assayed by enzyme linked immunosorbent assay. " 02/01/2015 - "Nidogen-1: a candidate biomarker for ovarian serous cancer." 11/15/2013 - "Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2." 01/01/2007 - "Immuno-staining for nidogen-2 confirmed the correlation between aberrant methylation and loss of nidogen expression also in primary tumors, implying that aberrant methylation was a mechanism for inhibiting nidogens expression in human gastrointestinal tumors. "
2.	Carcinoma (Carcinomatosis) 02/01/2015 - "Receiver operating characteristic curve analysis for nidogen-1 showed that it could discriminate patients with ovarian serous carcinomas from healthy controls [areas under the curve (AUC): 0. " 03/01/1999 - "The results show that nidogen is produced by human carcinoma cells both in vitro and in vivo." 03/01/1999 - "There was strong immunoreactivity for nidogen in tumour stroma, BM of carcinoma cell nests, and endothelial basal lamina, but no conclusions could be drawn regarding histological grade and immunostaining patterns, because stromal production could not be ruled out. " 09/15/1992 - "We report here the isolation and identification of the plasma membrane receptor for entactin from PC-3 human prostate carcinoma cells which attach and spread on entactin. " 02/01/2015 - "Our study suggests that plasma nidogen-1 may be used as a diagnostic biomarker for ovarian serous carcinoma and can reflect the tumor burden."
3.	Neoplasm Metastasis (Metastasis) 10/01/1990 - "The protease sensitivity of entactin suggests that it may be a target for proteolytic activity during tissue remodeling, metastasis, and other events requiring the turnover of the basement membrane." 04/01/2012 - "Taken together, these results suggest that absence of nidogen 2 might result in subtle changes of endothelial BMs in the lung, which would allow faster passage of tumor cells through these BMs, leading to a higher metastasis rate and more larger tumors." 01/01/2007 - "Loss of nidogen expression may favor invasion and metastasis of cancer cells by loosening cell interaction with basal membrane and by weakening the strength of the basement membrane itself, first barrier from the connective vascularized matrix." 03/01/1995 - "These observations suggest that a decrease in ER along with increased expression of nidogen and aromatase is associated with the process of metastasis and the model appears to be of value in studying the process of the acquisition of a metastatic phenotype." 04/01/2012 - "Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice."
4.	Melanoma (Melanoma, Malignant) 07/01/2011 - "Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk." 06/25/1990 - "Mouse entactin derived from the extracellular matrix of M1536-B3 cells and from insect cells infected with a recombinant virus containing entactin sequences were shown to promote the attachment of mouse mammary tumor, human melanoma, and other cells. " 01/01/1996 - "Altered production of laminin and nidogen by high and low metastatic variants of murine melanoma cells." 04/01/2012 - "However, studies in these mice revealed isoform-specific functions with nidogen 1-deficient mice showing neurological abnormalities and wound-healing defects not seen in the absence of nidogen 2. To investigate this further nidogen 1- or 2-deficient mice were intravenously injected with B16 murine melanoma cells, and lung metastasis was analyzed. " 04/01/2012 - "The authors could show that loss of nidogen 2, but not of nidogen 1, significantly promotes lung metastasis of melanoma cells. "
5.	Experimental Sarcoma 02/15/1988 - "Immunofluorescent studies, using the monoclonal antibody on sections of the EHS tumor after proteolytic digestion, showed that the retention or disappearance of the Nd-40 determinant correlated with the in vitro digestion pattern of the laminin-nidogen complex." 09/01/1992 - "Nidogen, obtained from the EHS tumor or in recombinant form, binds exclusively to the protein core in a heparin-insensitive manner. " 09/01/1992 - "A large, low-density form of heparan sulfate proteoglycan was isolated from the Engelbreth-Holm-Swarm (EHS) tumor and demonstrated to bind in immobilized-ligand assays to laminin fragment E3, collagen type IV, fibronectin and nidogen. " 08/01/1986 - "Further, the EBA antigen is absent from serum and blood components, placenta, amnion, lung, and the EHS tumor, a murine sarcoma that produces large amounts of laminin, type IV collagen, nidogen, entactin, and basement membrane proteoglycan but is present in cutaneous tumors of adnexal and epithelial origin. "

Related Drugs and Biologics

1.	Laminin (Merosin)
2.	nidogen (entactin)
3.	Collagen Type IV (Type IV Collagen)
4.	Collagen
5.	Antibodies
6.	heparin proteoglycan
7.	Tiopronin (Thiola)
8.	Fibronectins (Fibronectin)
9.	Proteins (Proteins, Gene)
10.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)

Related Therapies and Procedures

1.	Axotomy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Nephrectomy
4.	Drug Therapy (Chemotherapy)