phosphoribosylanthranilate isomerase

forms 1-(2-carboxyphenylamino)-1-deoxyribulose 5-phosphate; TrpF from Pseudomonas aeruginosa

Also Known As:

N-(5'-phosphoribosyl)anthranilate isomerase; N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase; N-5'-phosphoribosylanthranilate isomerase; PRA isomerase

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Aldose-Ketose Isomerases
        phosphoribosylanthranilate isomerase: 2

Related Diseases

Starvation

07/01/1977 - "During recovery from sulfate starvation or ammonium starvation, cultures slowly regain normal levels of InGP synthetase and PRA isomerase activities, suggesting that inactivation may be reversible."
07/01/1977 - "Phosphoribosylanthranilate (PRA) isomerase activity, which is also carried by the trpC protein, is unstable during starvation for ammonium, cysteine, or sulfate but is stable under other nongrowing conditions where InGP synthetase is not. "
09/10/1982 - "The bifunctional tryptophan biosynthetic enzyme N-(5'-phosphoribosyl)anthranilate (PRA) isomerase/indole-3-glycerol phosphate (InGP) synthetase was purified from Escherichia coli cultures incubated under several conditions, some of which result in inactivation of the enzyme (starvation for ammonium or sulfate, chloramphenicol inhibition). "

Related Drugs and Biologics

1.	Ammonium Compounds
2.	Sulfates (Sulfates, Inorganic)
3.	Ligases (Synthetase)
4.	Tryptophan (L-Tryptophan)
5.	Proteins (Proteins, Gene)
6.	Phosphates (Orthophosphate)
7.	Glycerol (Glycerine)
8.	Enzymes
9.	Cysteine (L-Cysteine)
10.	Chloramphenicol (Chloromycetin)