Protamines FDA Link

A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)

Also Known As:

Protamine Sulfate; Protamine Chloride; Chloride, Protamine; Sulfate, Protamine; Protamine

Pharmalogical Action Categories:

Heparin Antagonists

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nuclear Proteins: 2678
    - Protamines: 1607
  - Nucleoproteins: 1870
    - Protamines: 1607

Acipenser stellatus protamine A

Bio-Agent Context: Research Results