ailanthone

structure in first source

Also Known As:

Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1beta,11beta,12beta)-; ailantone; Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1beta,11beta,12alpha)-

Networked: 33 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Quassins: 86
        ailanthone: 33

Experts

1.	Liu, Mingyao: 4 articles (05/2020 - 12/2016)
2.	Peng, Shihong: 3 articles (05/2020 - 12/2016)
3.	Yi, Zhengfang: 3 articles (05/2020 - 12/2016)
4.	Ding, Haixiang: 2 articles (02/2022 - 08/2020)
5.	Yan, Zhilong: 2 articles (02/2022 - 08/2020)
6.	Yu, Xiuchong: 2 articles (02/2022 - 08/2020)
7.	Gao, Wei: 2 articles (01/2022 - 01/2019)
8.	Ge, Shuke: 2 articles (01/2022 - 01/2019)
9.	Min, Dejin: 2 articles (01/2022 - 01/2019)
10.	Sun, Jiayi: 2 articles (01/2022 - 01/2019)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 12/15/2022 - "Ailanthone (AIL) was screened out as a c-Jun inhibitor, and inhibited melanoma cell growth by directly targeting c-Jun and promoting its degradation. " 12/15/2022 - "The traditional chinese medicine monomer Ailanthone improves the therapeutic efficacy of anti-PD-L1 in melanoma cells by targeting c-Jun." 11/01/2019 - "Ailanthone may be potentially utilized as an anti-tumor agent in the management of malignant melanoma." 11/01/2019 - "However, the anti-tumor effect of ailanthone on malignant melanoma remains unclear. " 11/01/2019 - "To investigate the anti-tumor mechanisms of ailanthone in human melanoma B16 and mouse melanoma A375 cells, the cell counting kit-8 assay, colony formation assay, DNA content analysis, Hoechst 33258, and Annexin V-FITC/PI staining were used to assess cell proliferation, cell cycle distribution, and cell apoptosis, respectively. "
2.	Neoplasms (Cancer) 01/01/2021 - "Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing cell proliferation and invasion and inducing apoptosis, the mechanism by which Aila represses NSCLC progression in a time-dependent manner remains unclear. " 11/03/2015 - "In vivo studies demonstrated that ailanthone inhibited the growth and angiogenesis of tumor xenografts without significant secondary adverse effects, indicating its safety for treating HCC. " 01/01/2022 - "Ailanthone (AIL) refers to a natural compound isolated from Ailanthus altissima, a Chinese herbal medicine, and has effective anti-tumor activity in numerous cell lines. " 08/01/2020 - "Ailanthone: A novel potential drug for treating human cancer." 01/01/2020 - "It has been reported that Ailanthone (Aila), a compound extracted from the Ailanthus Altissima, has an anticancer activity toward several cancer cell lines, including chemoresistant cell lines. "
3.	Prostatic Neoplasms (Prostate Cancer) 05/01/2020 - "Collectively, these results and those from our previous study indicate that the pharmacokinetic properties of ailanthone are suitable for the potential development of this compound as an oral or intravenous drug for the treatment of castration-resistant prostate cancer." 07/01/2019 - "Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice." 01/01/2017 - "Ailanthone: a new potential drug for castration-resistant prostate cancer." 05/01/2020 - "This study aimed to evaluate the drug-like properties of ailanthone, a novel Chinese medicine monomer that was shown to have activity against castration-resistant prostate cancer tumour growth and metastasis in our previous study. " 12/13/2016 - "Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer."
4.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Retraction notice to "Ailanthone exerts anticancer effect by up-regulating miR-148a expression in MDA-MB-231 breast cancer cells and inhibiting proliferation, migration and invasion" [Biomed. " 01/01/2019 - "RETRACTED: Ailanthone exerts anticancer effect by up-regulating miR-148a expression in MDA-MB-231 breast cancer cells and inhibiting proliferation, migration and invasion." 04/01/2018 - "Breast cancer MCF-7 cells were treated with 0.5, 1.0, 2.0, 4.0 and 8.0 µg/ml ailanthone for 24, 48 and 72 h. " 04/01/2018 - "The present study revealed the presence of ailanthone-mediated antitumor effects, indicating that ailanthone may be a novel phytomedicine with potential use in breast cancer therapy." 04/01/2018 - "Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells."
5.	Neoplasm Metastasis (Metastasis) 05/01/2020 - "This study aimed to evaluate the drug-like properties of ailanthone, a novel Chinese medicine monomer that was shown to have activity against castration-resistant prostate cancer tumour growth and metastasis in our previous study. " 01/01/2022 - "The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway."

Related Drugs and Biologics

1.	MicroRNAs (MicroRNA)
2.	Quassins
3.	Pyridinolcarbamate (P23)
4.	Phytochemicals
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Anti-Allergic Agents (Antiallergic Agents)
7.	Serine (L-Serine)
8.	Bisbenzimidazole (Hoechst 33258)
9.	DNA (Deoxyribonucleic Acid)
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Castration
3.	Therapeutics