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substance P degrading enzyme

neutral metallo-endopeptidase from human brain

Also Known As:

SPD enzyme; substance P endopeptidase

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        substance P degrading enzyme: 4
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        substance P degrading enzyme: 4

Related Diseases

1.	Low Back Pain (Lumbago) 11/01/1990 - "The activity levels of a dynorphin converting enzyme (DCE), a substance P endopeptidase (SPE) and a substance P alpha-amidating enzyme (SP-GLYE) were measured in the cerebrospinal fluid (CSF) of 90 patients with chronic low back pain, sciatica and neurological signs of rhizopathy. "
2.	Hip Osteoarthritis (Coxarthrosis) 04/01/1996 - "We measured activities of dynorphin-converting enzyme (DCE), substance P endopeptidase (SPE) and angiotensin-converting enzyme (ACE) in cerebrospinal fluid (CSF) in 13 patients with rhizopathic pain from an herniated lumbar disc, in 9 patients with pain from coxarthrosis and in 11 control patients without pain. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/1997 - "The influence of the new antioxidant compound H-290/51 was examined on the substance P endopeptidase (SPE) activity in a rat model of spinal cord injury. "
4.	Sciatica (Sciatic Neuralgia) 11/01/1990 - "The activity levels of a dynorphin converting enzyme (DCE), a substance P endopeptidase (SPE) and a substance P alpha-amidating enzyme (SP-GLYE) were measured in the cerebrospinal fluid (CSF) of 90 patients with chronic low back pain, sciatica and neurological signs of rhizopathy. "
5.	Pain (Aches) 04/01/1996 - "We measured activities of dynorphin-converting enzyme (DCE), substance P endopeptidase (SPE) and angiotensin-converting enzyme (ACE) in cerebrospinal fluid (CSF) in 13 patients with rhizopathic pain from an herniated lumbar disc, in 9 patients with pain from coxarthrosis and in 11 control patients without pain. "

Related Drugs and Biologics

1.	dynorphin converting enzyme
2.	Substance P
3.	Enzymes
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
5.	Dynorphins (Dynorphin)
6.	Collagen
7.	Antioxidants
8.	H290-51
9.	dynorphin A-converting enzyme