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ribonuclease U

liver-spleen type of RNase; hydrolyzes poly C very poorly

Also Known As:

RNase 2; RNase PL1; RNase U; ribonuclease PL1

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        Endoribonucleases: 176
        ribonuclease U: 3
      - Endonucleases: 1227
        Endoribonucleases: 176
        ribonuclease U: 3

Experts

1.	Agarwal, Pratul K: 1 article (10/2017)
2.	Bafna, Khushboo: 1 article (10/2017)
3.	Charest, Laurie-Anne: 1 article (10/2017)
4.	Doucet, Nicolas: 1 article (10/2017)
5.	Gagné, Donald: 1 article (10/2017)
6.	Narayanan, Chitra: 1 article (10/2017)
7.	Farid, N R: 1 article (09/2005)
8.	Hackler, L: 1 article (09/2005)
9.	Juhasz, F: 1 article (09/2005)
10.	Puskas, L G: 1 article (09/2005)

Related Diseases

1.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/01/1990 - "The activities of RNase (RNase-U and RNase-C) were determined in the serum and leukocytes of 277 patients with 14 cases of various kinds of eosinophilia (not less than 10(3)/microliters), 28 cases of chronic myelocytic leukemia (CML), using polyuridylic acid and polycytidylic acid as synthetic substrates according to the method of Raddi et al. Serum RNase-U activity, serum RNase-C activity and the activity ratio (U/C x 10(-3)) were 55 +/- 14 U, 1,280 +/- 235 U and 44 +/- 11 (mean +/- SD), 196 +/- 137, 1,992 +/- 1,134 U and 97 +/- 38, and 110 +/- 50 U, 1,854 +/- 625 U and 65 +/- 13 for normal subjects, eosinophilia and CML (untreated), respectively. "
2.	Infections 10/01/2017 - "The functional homologs eosinophil-derived neurotoxin (EDN, or RNase 2) and eosinophil cationic protein (ECP, or RNase 3) are known to be expressed and secreted by eosinophils in response to infection, and have thus been postulated to play an important role in host defense and inflammatory response. "
3.	Eosinophilia 10/01/1990 - "Besides, serum and eosinophil RNase-U had a similar optimal pH. These results suggested that serum RNase-U in eosinophilia originated mostly from eosinophils and its rise was correlated strongly with the increase in eosinophils." 10/01/1990 - "U/C ratio in eosinophilia and CML (untreated) showed a highly significant positive correlation (p less than 0.001) with peripheral eosinophil count; the activity of serum RNase-U per cells in the supernatant of eosinophil homogenate rose significantly (p less than 0.001) compared with that of lymphocytes or granulocytes. " 10/01/1990 - "The activities of RNase (RNase-U and RNase-C) were determined in the serum and leukocytes of 277 patients with 14 cases of various kinds of eosinophilia (not less than 10(3)/microliters), 28 cases of chronic myelocytic leukemia (CML), using polyuridylic acid and polycytidylic acid as synthetic substrates according to the method of Raddi et al. Serum RNase-U activity, serum RNase-C activity and the activity ratio (U/C x 10(-3)) were 55 +/- 14 U, 1,280 +/- 235 U and 44 +/- 11 (mean +/- SD), 196 +/- 137, 1,992 +/- 1,134 U and 97 +/- 38, and 110 +/- 50 U, 1,854 +/- 625 U and 65 +/- 13 for normal subjects, eosinophilia and CML (untreated), respectively. "
4.	Papillary Thyroid Cancer 09/05/2005 - "SERP1, RNASE 2 and STATA5 were suppressed in papillary thyroid cancer. "

Related Drugs and Biologics

1.	Eosinophil-Derived Neurotoxin
2.	Eosinophil Cationic Protein
3.	Ribonucleases (Ribonuclease)
4.	Poly C
5.	Acids
6.	ribonuclease C