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hemoglobin Leiden

Glu residue is deleted from position 6 or 7 of the beta chain

Also Known As:

Hb Leiden

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Leiden: 2
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Leiden: 2

Related Diseases

1.	Hemolytic Anemia 10/01/1974 - "A mother and daughter of northern European ancestry with mild compensated hemolytic anemia were found to have 25% hemoglobin Leiden. " 01/01/1977 - "Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia." 01/01/1977 - "The first case of Hb Leiden (alpha2beta2 6 or 7 Glu---O)-beta (0) thalassemia in a young patient with chronic severe hemolytic anemia, which improved after splenectomy, is described. "
2.	Thalassemia 01/01/1977 - "His mother was heterozygous for beta(0) thalassemia, and his father and brother had a trait for the unstable Hb Leiden. " 01/01/1977 - "Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia." 01/01/1977 - "The first case of Hb Leiden (alpha2beta2 6 or 7 Glu---O)-beta (0) thalassemia in a young patient with chronic severe hemolytic anemia, which improved after splenectomy, is described. "
3.	beta-Thalassemia (Cooley's Anemia) 10/01/1974 - "This degree of predominance of alpha-chain synthesis in subjects with hemoglobin Leiden resembles the findings in heterozygous beta-thalassemia. "

Related Therapies and Procedures

1.	Splenectomy