vinylidene chloride (1,1-dichloroethylene)

01/01/1995 - "In male mice, 1,1-dichloroethene caused renal tumors after inhalation. "
12/01/1977 - "1,1-Dichloroethylene is reported to produce renal tumors in male mice. "
06/01/1981 - "Follow-up study on the carcinogenicity of vinyl chloride and vinylidene chloride in rats and mice: tumor incidence and mortality subsequent to exposure."
06/01/1994 - "HCFC-141b showed an equivocal tumorigenic effect in rats (an increase in benign testicular tumors that was not dose related), while vinylidene chloride was associated with an increase in tumor incidence (kidney tumors in mice) in a single study out of 19 in which its carcinogenicity has been investigated. "
12/15/1992 - "1,1-Dichloroethylene (125 mg/kg, i.p.) and naphthalene (225 mg/kg, i.p.) caused preferential necrosis of Clara cells in control lungs and uninvolved tissue of tumor-bearing lungs. "

08/01/2015 - "Toxicology and carcinogenesis studies of vinylidene chloride in F344/N rats and B6C3F1/N mice (inhalation studies)."
05/01/1982 - "A subchronic and a chronic carcinogenesis study of vinylidene chloride (99% pure), a widely used chemical intermediate and monomer, were conducted in F344/N rats and B6C3F1/N mice. "
05/01/1982 - "Carcinogenesis Bioassay of Vinylidene Chloride (CAS No. 75-35-4) in F344 Rats and B6C3F1 Mice (Gavage Study)."
08/01/1983 - "Vinylidene chloride: changes in drug-metabolizing enzymes, mutagenicity and relation to its targets for carcinogenesis."
01/01/1999 - "To test this hypothesis, we investigated 1,1-dichloroethylene (DCE), a chemical that causes Clara cell damage, in a urethane-induced model of lung tumorigenesis. "

01/01/1983 - "There were no significant differences between the groups of rats or dogs ingesting vinylidene chloride and their corresponding control groups in the following parameters: appearance and demeanor, mortality, body weight, food consumption, hematology, urinalysis, clinical chemistry determinations, organ weights and organ to body weight ratios. "
05/01/1982 - "In subchronic studies, groups of 10 rats and 10 mice of either sex were administered vinylidene chloride in corn oil by gavage five times per week at 0, 5, 15, 50, 100, or 250 mg/kg body weight for 13 weeks. "
01/01/1983 - "The vinylidene chloride was incorporated in the drinking water of the rats at nominal concentrations of 50, 100 or 200 ppm. The time weighted average mg/kg body weight/day dosages of vinylidene chloride administered to the male and female rats over the 2-year period at the various mean analyzed concentrations were 7, 10 or 20 for the males and 9, 14 or 30 for the females. "
01/01/1980 - "Vinylidene chloride (VDC) monomer dissolved in olive oil was given orally to female BD IV rats (150 mg/kg body weight) on the 17th day of gestation. "
01/01/1983 - "Dogs were administered vinylidene chloride in peanut oil incorporated in a gelatin capsule at concentrations which provided 6.25, 12.5 or 25 mg vinylidene chloride/kg body weight/day. "

06/01/1994 - "HCFC-141b showed an equivocal tumorigenic effect in rats (an increase in benign testicular tumors that was not dose related), while vinylidene chloride was associated with an increase in tumor incidence (kidney tumors in mice) in a single study out of 19 in which its carcinogenicity has been investigated. "

11/01/2001 - "1,1-Dichloroethylene (DCE) causes hepatocellular necrosis that preferentially affects centrilobular hepatocytes. "
02/15/1997 - "Exposure to 1,1-dichloroethylene (DCE) elicits lung and liver cytotoxicities that are manifested in bronchiolar Clara cell injury and centrilobular necrosis, respectively. "
07/01/1987 - "1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. "
08/01/1986 - "The administration of 1,1-dichloroethylene (1,1-DCE, 125 mg/kg ip) to CD-1 mice caused bronchiolar necrosis, which was accompanied by substantial covalent binding of radiolabeled compound and/or metabolite to lung. "
02/01/1986 - "Administration of a single intraperitoneal dose of 1,1-dichloroethylene (125 mg/kg, 1,1-DCE) to mice resulted in bronchiolar injury with selective necrosis of Clara cells. "