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asparaginyl-tRNA synthetase

GenbBank AJ222644 (Arabidopsis); RefSeq NM_004539 (human)
Also Known As:
ATNS1 protein, Arabidopsis; Asn-tRNA synthetase; AsnRS enzyme; Asparaginyl-tRNA synthetase protein, Arabidopsis; Cytosolic asparaginyl-tRNA synthetase protein, S cerevisiae; DED81 protein, S cerevisiae; L-asparaginyl tRNA synthetase; Mitochondrial asparaginyl-tRNA synthetase protein, S cerevisiae; NARS protein, human; NS1 protein, Arabidopsis; YCR024C protein, S cerevisiae; YHR019C protein, S cerevisiae; asparagine - tRNA ligase; asparagine-tRNA synthetase; asparaginyl tRNA synthetase; asparaginyl-tRNA synthetase protein, human; cytosolic asparaginyl-tRNA synthetase protein, human
Networked: 23 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kron, Michael: 5 articles (01/2019 - 09/2002)
2. Ahmed, Zubair M: 2 articles (01/2020 - 03/2015)
3. Riazuddin, Saima: 2 articles (01/2020 - 03/2015)
4. Dhanasekaran, Anuradha: 2 articles (01/2019 - 01/2016)
5. Sivanesan, Sanjana: 2 articles (01/2019 - 01/2016)
6. Kron, Michael A: 2 articles (02/2013 - 01/2005)
7. Vodanovic-Jankovic, Sanja: 2 articles (02/2013 - 04/2011)
8. Dong, Hui Fang: 2 articles (06/2005 - 09/2002)
9. Howard, O M Zack: 2 articles (06/2005 - 09/2002)
10. Oppenheim, Joost J: 2 articles (06/2005 - 09/2002)

Related Diseases

1. Myositis (Idiopathic Inflammatory Myopathies)
05/01/2020 - "Several reports recently described different characteristics depending on the individual anti-ARS antibodies, and the anti-asparaginyl tRNA synthetase (KS) antibody was strongly linked to ILD rather than to myositis. "
01/01/2005 - "A subset of patients with idiopathic inflammatory myopathies demonstrate autoantibody against specific cytoplasmic AARS and the human asparaginyl-tRNA synthetase (AsnRS) has been shown to be a potent chemokine that interacts with CCR3 chemokine receptors. "
09/16/2002 - "Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells."
06/01/2005 - "Our initial observation that myositis-associated autoantigens, histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, were chemotactic for CC chemokine receptor 5 (CCR5)- and CCR3-expressing leukocytes, while other nonautoantigenic aminoacyl-tRNA synthesases were not, suggested that only self-antigens capable of interacting with receptors on antigen-presenting cells were immunogenic. "
02/15/1999 - "Serum KS, from a patient with ILD and inflammatory arthritis without evidence of myositis, immunoprecipitated a tRNA that was distinct from that precipitated by any described anti-synthetase or other reported tRNA-related Abs, along with a protein of 65 kDa. KS serum and IgG fraction each showed significant (88%) inhibition of asparaginyl-tRNA synthetase (AsnRS) activity, but not of any of the other 19 aminoacyl-tRNA synthetase activities. "
2. Filarial Elephantiasis (Lymphatic Filariasis)
3. Interstitial Lung Diseases (Interstitial Lung Disease)
4. Nonsyndromic Deafness
5. Carcinogenesis

Related Drugs and Biologics

1. Chemokine Receptors
2. Transfer RNA (tRNA)
3. Ligases (Synthetase)
4. Histidine-tRNA Ligase
5. Autoantigens
6. CCR5 Receptors (CCR5 Receptor)
7. Chemokines
8. Interleukin-8 (Interleukin 8)
9. Proteins (Proteins, Gene)
10. Immunoglobulin G (IgG)

Related Therapies and Procedures

1. Chinese Traditional Medicine (Traditional Chinese Medicine)