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procalcitonin

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glycoprotein precursor of unglycosylated 32 amino acid hormone; RefSeq NM_001741 (human)

Also Known As:

CALC1 protein, human; CALCA protein, human; CGRP1 protein, human; CGRP1 protein, mouse; calcitonin precursor polyprotein; calcitonin/calcitonin-related polypeptide, alpha protein, human; Calcitonin, pro-

Networked: 2244 relevant articles (93 outcomes, 450 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schuetz, Philipp: 47 articles (09/2015 - 08/2005)
2.	Müller, Beat: 35 articles (10/2015 - 10/2002)
3.	Christ-Crain, Mirjam: 35 articles (03/2015 - 02/2004)
4.	Mueller, Beat: 29 articles (09/2015 - 04/2004)
5.	Gervaix, Alain: 16 articles (11/2014 - 04/2003)
6.	Gendrel, Dominique: 15 articles (08/2015 - 06/2005)
7.	Becker, Kenneth L: 14 articles (10/2013 - 10/2002)
8.	Chalumeau, Martin: 14 articles (05/2013 - 06/2005)
9.	Nobre, Vandack: 13 articles (10/2015 - 03/2008)
10.	Chastre, Jean: 12 articles (12/2015 - 01/2005)

Related Diseases

1.	Sepsis (Septicemia) 10/01/2002 - "Amino-prohormone procalcitonin-reactive antiserum administration resulted in a significant improvement or a beneficial trend in a majority of the measured physiologic and metabolic derangements induced by sepsis. " 11/01/2007 - "Ultrasensitive assays for procalcitonin, capable of measuring low levels in healthy individuals, may help to identify even 'subclinical' inflammatory states before the development of clinically evident sepsis. " 02/01/2001 - "The amount of procalcitonin eliminated in the urine and the plasma disappearance rate of procalcitonin were evaluated in patients with normal and impaired renal function, because patients with sepsis are a main target group for procalcitonin measurement, and these patients often develop renal dysfunction. " 11/01/2008 - "Using procalcitonin to diagnose sepsis and the potential for improved antibiotic stewardship." 07/01/2015 - "Early-Onset Neonatal Sepsis: Still Room for Improvement in Procalcitonin Diagnostic Accuracy Studies."
2.	Infection 06/13/2009 - "In most infections a true gold standard for diagnosis does not exist, therefore physicians must remain sceptical towards observational studies evaluating procalcitonin. " 01/01/2014 - "Procalcitonin has been heralded as the biomarker that holds the most promise for bloodstream infections. " 06/01/2015 - "Recent clinical studies suggest that a significant reduction in antibiotic consumption may be achieved by procalcitonin-guided algorithms without sacrificing the outcome of patients with severe infection. " 07/01/2012 - "Procalcitonin levels for intensive care unit transfers for probable or definite infection were 2.28 ng/mL [interquartile range 0.68-8.05], and were significantly greater than rapid response team visits that did not result in transfer (p = .0001). " 02/01/2014 - "A procalcitonin ≥0.85 ng/ml might be helpful for early identifying CKD patients with infection."
3.	Bacterial Infections (Bacterial Infection) 01/01/2010 - "Although the exact physiologic function of procalcitonin has not been determined, the consistent response and rapid rise of this protein in the setting of severe bacterial infection make procalcitonin a very useful biomarker for invasive bacterial disease. " 01/01/2010 - "Procalcitonin is superior to other commonly used markers in its specificity for bacterial infection (allowing alternative diagnoses to be excluded), as an indicator of disease severity and risk of death, and mainly as a guide to the necessity for antibiotic therapy. " 01/01/2014 - "Procalcitonin (PCT) is helpful for diagnosing bacterial infections. " 04/13/2004 - "We hypothesized that serum procalcitonin, a marker of systemic bacterial infection, might be helpful in its diagnosis. " 11/01/2015 - "The aim of this study was to evaluate the use of procalcitonin in the assessment of bacteraemia in patients in the emergency department, both alone and in conjunction with existing inflammatory markers of bacterial infection. "
4.	Pneumonia (Pneumonitis) 03/01/2013 - "Biomarker interest centres on procalcitonin, which has given good results particularly for pneumonias, though broader biomarker arrays may prove superior in the future. " 03/01/2012 - "Promising results in relation to severity assessment and treatment of patients with community-acquired pneumonia (CAP) have recently been presented from the study of procalcitonin (PCT) levels in these patients. " 03/01/2014 - "Procalcitonin-guided antibiotic therapy for community-acquired pneumonia is effective and safe. " 07/01/2008 - "Adding procalcitonin to the Pneumonia Severity Index in all subjects minimally improved performance. " 01/01/2007 - "Efficacy of serum procalcitonin in evaluating severity of community-acquired pneumonia in childhood."
5.	Septic Shock (Toxic Shock Syndrome) 12/01/2003 - "To measure the mass transfer and clearance of procalcitonin (PCT) in patients with septic shock during continuous venovenous hemofiltration (CVVH), and to assess the mechanisms of elimination of PCT. " 01/01/2015 - "The objective of this study was to present a case report that highlights the limitation of serum procalcitonin levels greater than 10 ng/mL as being almost exclusively secondary to septic shock. " 01/01/2014 - "This study evaluated the value of procalcitonin in predicting RAI and mortality in cirrhotic patients with septic shock. " 09/01/2008 - "In conclusion, this study found that the prognostic utility of serum sTREM-1 in septic shock is poor and that procalcitonin measurements perform better in this regard." 09/01/2008 - "This study aimed to evaluate the prognostic utility of serum sTREM-1 in septic shock, in comparison with that of procalcitonin measurements. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Biological Markers (Surrogate Marker)
3.	Interleukin-6 (Interleukin 6)
4.	Lactic Acid
5.	Calcitonin (Calcitonin, Eel)
6.	proadrenomedullin
7.	Interleukin-8 (Interleukin 8)
8.	Interleukins
9.	Anti-Bacterial Agents (Antibiotics)
10.	Serum Amyloid A Protein (Serum Amyloid A)

Related Therapies and Procedures

1.	Critical Care
2.	Intensive Care (Surgical Intensive Care)
3.	Arthroplasty
4.	Enteral Nutrition (Feeding, Tube)
5.	Resuscitation