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FPL-52694
mast cell stabilizer; RN given refers to parent cpd; FPL-52694 is mono-Na salt; structure given in first source
Also Known As:
FPL 52694; FPL-52694, monosodium salt
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
FPL-52694: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
FPL-52694: 5
Related Diseases
1.
Ulcer
06/01/1984 - "
Intraduodenal FPL-52694 also inhibited pylorus-ligated ulcers whereas it had no effect on aspirin-induced gastric erosions.
"
06/01/1984 - "
Oral FPL-52694 markedly inhibited the development of pylorus-ligated ulcers, water-immersion stress- and aspirin-induced gastric erosions and moderately inhibited the formation of reserpine-induced gastric erosions in rats.
"
03/25/1983 - "
The anti-ulcer activities of atropine, FPL 52694 and cimetidine are discussed in relation to their gastric anti-secretory actions.
"
2.
Fistula
01/01/1983 - "
Inhibition of gastric acid secretion in conscious dog with fistula following intragastric administration of FPL 52694.
"
09/01/1983 - "
Instillation of FPL 52694 (4.35 mg ml-1) directly into the stomach via the fistula for 30 min also resulted in an inhibition of acid output and reduction of [H+] during both pentagastrin-(2 micrograms kg-1 h-1) and histamine-stimulated (30 micrograms kg-1 h-1) secretion.
"
3.
Peptic Ulcer (Peptic Ulcers)
06/01/1984 - "
Although the precise mechanism of action of FPL-52694 remains unknown, oral FPL-52694 appears to be a promising agent for the treatment of peptic ulcers.
"
4.
Immediate Hypersensitivity
01/01/1985 - "
The substituted chromone carboxylic acid FPL 52694 inhibited models of IgE-mediated immediate hypersensitivity reactions in the rat by a mechanism similar to that of sodium cromoglycate.
"
5.
Duodenal Ulcer (Curling's Ulcer)
03/25/1983 - "
FPL 52694, 300 mg/kg orally, reduced the incidence, number, size and severity of cysteamine-induced duodenal ulcers in rats and mice.
"
03/25/1983 - "
The effect of atropine, cimetidine and FPL 52694 on duodenal ulcers in mice.
"
Related Drugs and Biologics
1.
Reserpine (Serpasil)
2.
Immunoglobulin E (IgE)
3.
Histamine (Histamine Dihydrochloride)
4.
Cromolyn Sodium (Cromoglicic Acid)
5.
Cysteamine (Mercaptamine)
6.
Cimetidine (Biomet)
7.
Chromones
8.
Carboxylic Acids
9.
Atropine
10.
Aspirin (Acetylsalicylic Acid)