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FPL-52694

mast cell stabilizer; RN given refers to parent cpd; FPL-52694 is mono-Na salt; structure given in first source

Also Known As:

FPL 52694; FPL-52694, monosodium salt

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        FPL-52694: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        FPL-52694: 5

Related Diseases

1.	Ulcer 06/01/1984 - "Intraduodenal FPL-52694 also inhibited pylorus-ligated ulcers whereas it had no effect on aspirin-induced gastric erosions. " 06/01/1984 - "Oral FPL-52694 markedly inhibited the development of pylorus-ligated ulcers, water-immersion stress- and aspirin-induced gastric erosions and moderately inhibited the formation of reserpine-induced gastric erosions in rats. " 03/25/1983 - "The anti-ulcer activities of atropine, FPL 52694 and cimetidine are discussed in relation to their gastric anti-secretory actions."
2.	Fistula 01/01/1983 - "Inhibition of gastric acid secretion in conscious dog with fistula following intragastric administration of FPL 52694." 09/01/1983 - "Instillation of FPL 52694 (4.35 mg ml-1) directly into the stomach via the fistula for 30 min also resulted in an inhibition of acid output and reduction of [H+] during both pentagastrin-(2 micrograms kg-1 h-1) and histamine-stimulated (30 micrograms kg-1 h-1) secretion. "
3.	Peptic Ulcer (Peptic Ulcers) 06/01/1984 - "Although the precise mechanism of action of FPL-52694 remains unknown, oral FPL-52694 appears to be a promising agent for the treatment of peptic ulcers."
4.	Immediate Hypersensitivity 01/01/1985 - "The substituted chromone carboxylic acid FPL 52694 inhibited models of IgE-mediated immediate hypersensitivity reactions in the rat by a mechanism similar to that of sodium cromoglycate. "
5.	Duodenal Ulcer (Curling's Ulcer) 03/25/1983 - "FPL 52694, 300 mg/kg orally, reduced the incidence, number, size and severity of cysteamine-induced duodenal ulcers in rats and mice. " 03/25/1983 - "The effect of atropine, cimetidine and FPL 52694 on duodenal ulcers in mice."

Related Drugs and Biologics

1.	Reserpine (Serpasil)
2.	Immunoglobulin E (IgE)
3.	Histamine (Histamine Dihydrochloride)
4.	Cromolyn Sodium (Cromoglicic Acid)
5.	Cysteamine (Mercaptamine)
6.	Cimetidine (Biomet)
7.	Chromones
8.	Carboxylic Acids
9.	Atropine
10.	Aspirin (Acetylsalicylic Acid)