crocin

01/01/2022 - "Crocin caused a significant reduction of levels of TNF-α and IL-1β, suggesting that crocin suppressed inflammation in BC cells. "
01/01/2021 - "Conclusion: The protective effects of crocin on UC and CRC were due to its suppression of NF-κB-mediated inflammation."
09/01/2022 - "In conclusion, Crocin may be helpful in pathological conditions that are associated with inflammation and oxidative stress."
01/01/2022 - "This study tried to explore the influences of crocin on proliferation and inflammation of BC cells, and to investigate the possible mechanism. "
01/01/2021 - "The results of this review indicated that saffron and its main ingredients such as crocin could be a potential candidate for the treatment of ocular disease especially eye inflammation; however, further clinical studies are needed to confirm such efficiency."

09/01/2015 - "Results after ischemia and reperfusion showed that crocin 40 mg/kg produced a significant improvement of LVEDP as a mechanical function (p<0.05), associated with a reduction of iNOS release (p<0.05). "
01/01/2016 - "The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats. "
01/01/2015 - "In the present study, we investigated the antioxidative effect of crocin and the change of the ERK signaling pathway on rat retina induced by ischemia/reperfusion (IR) injury. "
08/22/2005 - "This study therefore suggests that the aqueous saffron extract (Crocus sativus L.) and its active constituent, crocin, may be useful agents for the prevention of renal ischemia-reperfusion (IR)-induced oxidative injury in rats."
01/01/2020 - "Crocin sufficiently promotes the proliferation and migration of neural stem cells and inhibits the apoptosis of these cells in rats after ischemia-reperfusion by manipulating the Notch signalling pathway."

01/01/2020 - "Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling."
01/01/2020 - "The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D. "
12/15/2021 - "The present study showed that intragastric treatment of crocin prevented weight gain, fat accumulation, and insulin resistance in OVX mice by increasing energy expenditure and fat oxidation. "
05/01/2020 - "Also, crocin protected against the occurrence of hyperglycemia and insulin resistance as indicated by controlled values of HOMA-IR. "
10/01/2016 - "Crocin combined with voluntary exercise improved insulin resistance (HOMA-IR) and reduced glucose levels in diabetic rats. "

09/30/2011 - "Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats."
08/01/2023 - "The aim of the current study was to investigate the probable mechanism and effect of crocin on brain oxidative damage and memory deficits induced by unpredictable chronic mild stress (UCMS). "
08/01/2023 - "Also behavioral test demonstrated a positive effect of crocin on memory deficit induced by UCMS. "
06/01/2021 - "Crocin at all doses restored TSD-induced memory deficits. "
01/01/2021 - "Pretreatment with crocin attenuates spatial or aversive learning and memory deficits in LPS-treated rats."

11/01/2020 - "This study examined the cardioprotective effects of crocin and explored their mechanistic involvement in ATO-induced cardiotoxicity. "
01/01/2021 - "Hence, Crocin could be potentially used as an adjuvant treatment in combination with Dox to reduce cardiotoxicity."
07/01/2020 - "So the objective of our investigation is to identify the cardioprotective action of crocin (CRO), a natural compound derived from saffron, against DOX-induced cardiotoxicity. "
03/01/2010 - "The results suggest that crocin may have cardioprotective effect in ISO-induced cardiac toxicity through modulation of oxidative stress in such a way that maintains the redox status of the cell."
12/01/2019 - "The observed results revealed that crocin has preventive effects on the LPS induced sepsis and its cardiac toxicity in-vitro model. "