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timegadine
first source states that SR 1368 is synonym for cpd; SR 1368 is a different cpd in Chemline; structure given in first source
Also Known As:
N-cyclohexyl-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolylguanidine
Networked:
13
relevant articles (
4
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amidines: 14
Guanidines: 29
timegadine: 13
Related Diseases
1.
Rheumatoid Arthritis
12/01/1983 - "
Timegadine: long-term open study in rheumatoid arthritis.
"
01/01/1988 - "
Timegadine: more than a non-steroidal for the treatment of rheumatoid arthritis.
"
01/01/1988 - "
Timegadine is superior to naproxen in controlling disease activity in rheumatoid arthritis, and appears to possess disease-modifying properties.
"
12/01/1983 - "
The clinical results suggest that Timegadine is as effective as D-penicillamine in the treatment of rheumatoid arthritis.
"
01/01/1988 - "
In a 24-week randomized double-blind controlled trial, timegadine 500 mg/day was compared with naproxen 750 mg/day in two groups of 20 patients with active rheumatoid arthritis.
"
2.
Leukocytosis (Pleocytosis)
07/01/1981 - "
Detailed studies in adjuvant arthritic rats showed: (a) long dosing regimen with timegadine inhibited primary and secondary lesions, leukocytosis and hyperfibrinogemia, (b) timegadine was significantly active in reducing the severity of the already established disease, (c) a short course of dosing with timegadine at the time of adjuvant injection permanently prevented the development of secondary lesions.
"
3.
Joint Diseases (Joint Disease)
04/01/1988 - "
It is concluded that the release of histamine from mast cells may be modulated to some extent by anti-inflammatory drugs, especially auranofin, BW 755c and timegadine, a functional property which may be beneficial in the management of joint disease.
"
4.
Edema (Dropsy)
03/01/1985 - "
While indomethacin, a cyclooxygenase inhibitor, primarily inhibits edema formation, the inhibition of both pathways of arachidonic acid metabolism by timegadine is reflected in the drug's ability to reduce cellular influx as well as edema formation in the RPAR pleural cavity inflammatory reaction.
"
07/01/1981 - "
Timegadine (SR 1368, N-cyclohexyl-N"-4-(2-methylguinolyl)-N'-2-thiazolylguanidine) dose-dependently inhibited carrageenan-, nystatin-, and concanavalin A-induced edema.
"
12/01/1985 - "
Several cyclooxygenase (CO) inhibitors including indomethacin, aspirin, piroxicam and timegadine were without effect when administered orally against either irritant; the same drugs inhibited TPA edema when they were administered topically.
"
5.
Neoplasms (Cancer)
07/01/1986 - "
Rat splenic natural killer (NK) cell activity against 51Cr-labeled YAC-1 or TMT-081 tumor cells can be augmented by culturing at 37 degrees C for 18 hr. Inhibitors of the lipoxygenase pathway of arachidonic acid metabolism, NDGA, alpha-phenanthroline, quercetin, ETYA, BW755C, esculetin, and timegadine, inhibited this NK activation and also inhibited NK cytotoxicity when added directly to the NK assay.
"
Related Drugs and Biologics
1.
Naproxen (Naprosyn)
2.
Penicillamine (Cuprimine)
3.
4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
4.
Histamine (Histamine Dihydrochloride)
5.
Auranofin (Ridaura)
6.
Antirheumatic Agents (DMARD)
7.
Indomethacin (Indometacin)
8.
Arachidonic Acid (Vitamin F)
9.
Piroxicam (Feldene)
10.
Aspirin (Acetylsalicylic Acid)