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pralidoxime (Protopam Chloride)

Subscribe to New Research on pralidoxime

RN given refers to parent cpd; chloride was minor descriptor (75-80); on-line & Index Medicus search PRALIDOXIME COMPOUNDS (66-80)

Also Known As:

Protopam Chloride; pralidoxime chloride; 1-methylpyridinium-2-aldoxime ion; 2-PAM; 2-PAM chloride; 2-Pam bromide; 2-formyl-1-methylpyridinium chloride oxime; 2-hydroxyiminomethyl-1-methylpyridinium; 2-hydroxyiminomethylpyridinium methylmethanesulfonate; Contrathion; N-methylpyridinium 2-aldoxime methylsulfate; Protopam; SERB brand of pralidoxime mesylate; Wyeth brand of pralidoxime chloride; pralidoxime bromide; pralidoxime fumarate (1:1); pralidoxime iodide; pralidoxime lactate (1:1); pralidoxime mesylate; pralidoxime methyl sulfate; pralidoxime nitrate (1:1); pralidoxime sulfate (1:1); pralidoxime trichloroacetate; pralidoxime, 14C-labeled; pyridine-2-aldoxime methachloride; pyridine-2-aldoxime methiodide; pyridine-2-aldoxime methochloride

Networked: 239 relevant articles (33 outcomes, 27 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Hydroxylamines: 10
    - Oximes: 320
      - Pralidoxime Compounds: 1
        pralidoxime: 239

Experts

1.	Eddleston, Michael: 8 articles (12/2013 - 05/2008)
2.	Kuca, Kamil: 6 articles (12/2011 - 11/2005)
3.	Worek, Franz: 5 articles (12/2013 - 06/2009)
4.	Houzé, Pascal: 5 articles (04/2011 - 01/2005)
5.	Eyer, Peter: 5 articles (09/2010 - 01/2003)
6.	Hoffman, Robert S: 4 articles (12/2013 - 07/2004)
7.	Thiermann, Horst: 4 articles (12/2013 - 09/2010)
8.	Jokanović, Milan: 4 articles (01/2012 - 12/2006)
9.	Worek, F: 4 articles (09/2011 - 06/2007)
10.	Meggs, William J: 3 articles (04/2013 - 01/2003)

Related Diseases

1.	Poisoning 10/01/1998 - "High doses of pralidoxime (30 mg/kg followed by 8 mg/kg/h) did not induce serious side effects and may be effective in some OP pesticides poisoning." 07/01/1987 - "Poisindex, a widely used poisoning treatment resource, recommends dosing pralidoxime chloride as an intermittent iv infusion every 8-12 hours, whereas other authors have used continuous iv infusion with good results. " 01/01/2015 - "Is the World Health Organization-recommended dose of pralidoxime effective in the treatment of organophosphorus poisoning? " 03/01/2010 - "Pros: PAM (pralidoxime) is effective for acute poisoning of organophosphorus]." 01/01/2014 - "The efficacy of pralidoxime in organophosphorus poisoning: a commentary."
2.	Necrosis 09/01/2002 - "The earlier the administration of pralidoxime the greater the protection against muscle necrosis. " 09/01/2002 - "Results support the current opinion that pralidoxime should be administered as soon as possible after organophosphate intoxication, because in addition to reversing the muscarinic effects, early administration of pralidoxime also prevents muscle necrosis--which could impair muscular function and respiratory condition. " 09/01/2002 - "The fiber necrosis of the diaphragm muscle was quantified by a morphometric technique, comparing the area fraction occupied by necrotic muscle fibers in animals that received pralidoxime at different times after intoxication, i.e., 0, 1, 3, 6, and 12 h. " 09/01/2002 - "Protective effect of early and late administration of pralidoxime against organophosphate muscle necrosis." 01/01/1998 - "To determine the protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate acute intoxication in rats. "
3.	Wounds and Injuries (Trauma) 06/01/2007 - "The results obtained with the two sarin analogues indicate that the direct reaction with 2-PAM, obidoxime, or HI 6 could be used for non-corrosive decontamination purposes, especially, if sensitive biological surfaces like skin, mucous membranes, or wounds are considered. " 05/01/1991 - "The specific objectives of this research were: (1) to determine the pathophysiologic effects of combined injuries from sublethal amounts of an organophosphate (soman) along with hypovolemic shock, and (2) to determine the efficacy of atropine sulfate and pralidoxime (2-PAM) therapy for organophosphate poisoning when combined injuries occur. "
4.	Shock 05/01/1991 - "The specific objectives of this research were: (1) to determine the pathophysiologic effects of combined injuries from sublethal amounts of an organophosphate (soman) along with hypovolemic shock, and (2) to determine the efficacy of atropine sulfate and pralidoxime (2-PAM) therapy for organophosphate poisoning when combined injuries occur. "
5.	Acute Kidney Injury (Acute Renal Failure) 01/10/2009 - "Our study showed acute renal failure does not modify the distribution of pralidoxime but significantly alters its elimination from plasma. " 08/25/2009 - "We recently showed in a rat model of dichromate-induced acute renal failure (ARF) that the elimination but not the distribution of pralidoxime was altered resulting in sustained plasma pralidoxime concentrations. " 01/10/2009 - "Acute renal failure alters the kinetics of pralidoxime in rats." 08/25/2009 - "The aim of this study was to compare the efficiency of pralidoxime in normal and acute renal failure rats against paraoxon-induced respiratory toxicity. " 08/25/2009 - "Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity."

Related Drugs and Biologics

1.	Atropine (Hyoscyamine)
2.	Oximes
3.	Obidoxime Chloride (Obidoxime)
4.	HI 6 (H16)
5.	Soman
6.	Sarin
7.	VX (EDIM)
8.	Cholinesterases (Cholinesterase)
9.	Pyridostigmine Bromide (Pyridostigmine)
10.	Acetylcholinesterase

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Transdermal Patch
3.	Artificial Respiration (Mechanical Ventilation)
4.	Aftercare (After-Treatment)
5.	Airway Management