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etofylline clofibrate
whole issue; structure given in first source
Also Known As:
4-chlorophenoxyisobutyrate theophylline-7-ethyl ester; Duolip; ML 1024; etofyllinclofibrate; etophylline clofibrate
Networked:
15
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Phenyl Ethers: 8
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
etofylline clofibrate: 15
Carboxylic Acids: 973
Acyclic Acids
Butyrates: 2613
Isobutyrates: 2
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
etofylline clofibrate: 15
Ethers: 242
Phenyl Ethers: 8
Fibric Acids: 1474
Clofibric Acid: 75
Clofibrate: 861
etofylline clofibrate: 15
Related Diseases
1.
Hyperlipidemias (Hyperlipidemia)
10/01/1995 - "
We conclude that hypolipidemic treatment with etophylline clofibrate favorably affects the cardiovascular risk factor profile in primary mixed hyperlipidemia.
"
01/01/1993 - "
[The mechanisms of action of etophylline-clofibrate in hyperlipidemia].
"
09/22/1983 - "
During an 8-months treatment period the effect of Duolip on serum uric acid in 112 patients with hyperlipidemia was studied.
"
10/01/1995 - "
Treatment of primary mixed hyperlipidemia with etophylline clofibrate: effects on lipoprotein-modifying enzymes, postprandial lipoprotein metabolism, and lipoprotein distribution and composition.
"
03/08/1995 - "
[Use of etofyllinclofibrate (Duolip Forte) in combined hyperlipidemia].
"
2.
Thrombosis (Thrombus)
09/01/1986 - "
The antithrombotic efficacy found in both in vivo tests, thrombus formation and disaggregation, suggests as mode of action of etofylline clofibrate an agonistic interaction with intimal PGI2.
"
01/01/1980 - "
Effect of etofylline clofibrate on experimental thrombosis and platelet function.
"
09/01/1986 - "
Effect of etofylline clofibrate on experimental thrombus formation and prostacyclin activation.
"
09/01/1986 - "
1-(7-Theophyllinyl)-2-ethyl-[2-(p-chlorophenoxy)-isobutyrate] (etofylline clofibrate, theofibrate, Duolip) was shown to possess substantial thrombus disaggregating activity in the microcirculation of the hamster cheek pouch following minor vascular damage by electrical stimulation.
"
01/01/1980 - "
1-(Theophyllin-7yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was shown to be a potent inhibitor of experimental thrombus formation in the microvasculature of the hamster cheek pouch and of platelet aggregation and adhesiveness in the cynomolgus monkey.
"
3.
Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
04/01/1995 - "
[Etophylline clofibrate in the treatment of familial combined hyperlipoproteinemia].
"
04/01/1985 - "
The effect of etophylline clofibrate on lipids and apolipoproteins of the high density lipoprotein (HDL) subfractions HDL2 and HDL3 as well as on very low density (VLDL) and low density lipoproteins (LDL) and the post heparin lipolytic activities (PHLA) of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) has been studied in 14 patients with type II hyperlipoproteinemia (HLP).
"
4.
Body Weight (Weight, Body)
05/18/1993 - "
In the course of six months of Duolip administration the body weight of the patients did not change and no serious side-effects were observed which would call for discontinuation of treatment.
"
03/01/1989 - "
Terminal maternal body weight was significantly decreased after all doses of etofylline clofibrate in a non-dose-related fashion compared to the control group.
"
5.
Teratogenesis
01/01/1977 - "
1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (ML 1024) was tested on acute and chronic toxicity, on teratogenesis and fetotoxicity, on blood pressure and blood flow behaviour, on hypolipemic activity and general pharmacological behaviour in a screening test using 54 parameters.
"
Related Drugs and Biologics
1.
etofylline clofibrate
2.
Lipids
3.
Fenofibrate (CiL)
4.
Lipoproteins (Lipoprotein)
5.
Vitamin A (Retinol)
6.
Uric Acid (Urate)
7.
Insulin Receptor
8.
Epoprostenol (Prostacyclin)
9.
LDL Lipoproteins (beta Lipoproteins)
10.
HDL Lipoproteins
Related Therapies and Procedures
1.
Therapeutics
2.
Reducing Diet
3.
Aftercare (After-Treatment)