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urinastatin (MR 20)

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a multivalent Kunitz-type serine protease inhibitor that is found in human urine and blood; MW about 68 kDa; widely used as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation, shock, and pancreatitis; has anti-inflammatory properties

Also Known As:

MR 20; MR 20 (magnetic powder) of urinastatin; MR-20 (magnetic powder); Miraclid; UTI(68); UTI68; acid-stable protease inhibitor; trypsin inhibitor MR-20; ulinastatin; urinary trypsin inhibitor; urinary trypsin inhibitor (68); urinary trypsin inhibitor-like inhibitor (43)

Networked: 429 relevant articles (81 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takano, Hirohisa: 7 articles (04/2010 - 03/2005)
2.	Yoshikawa, Toshikazu: 6 articles (07/2009 - 03/2005)
3.	Yanagisawa, Rie: 6 articles (07/2009 - 03/2005)
4.	Sun, Zhijun: 5 articles (04/2013 - 01/2011)
5.	Sun, Xin: 5 articles (04/2013 - 01/2011)
6.	Sato, Hiroyuki: 5 articles (07/2009 - 03/2005)
7.	Su, Lei: 4 articles (08/2015 - 03/2009)
8.	Yang, Yu: 4 articles (02/2015 - 11/2011)
9.	Qiu, Wei: 4 articles (02/2015 - 11/2011)
10.	Tsujino, Takeshi: 4 articles (12/2013 - 04/2005)

Related Diseases

1.	Pancreatitis 01/01/2007 - "Short-term (10 minutes) administration of ulinastatin showed a significant reduction in the incidence of post-ERCP pancreatitis in one randomized controlled trial. " 06/01/2014 - "Ulinastatin is a drug used effectively to alleviate symptoms and improve the pathophysiology of various types of pancreatitis. " 07/01/2013 - "Ulinastatin has been shown to be effective for the prevention of pancreatitis following endoscopic retrograde cholangiopancreatography. " 01/01/2006 - "Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis." 11/01/2010 - "A meta-analysis of all published randomized clinical trials was performed to evaluate the efficacy of ulinastatin on post-ERCP pancreatitis. "
2.	Sepsis (Septicemia) 11/01/2013 - "Ulinastatin was also found to be effective in ameliorating sepsis-related ALI, a syndrome most frequent and fatal in sepsis. " 09/01/2012 - "However, it is unknown if Ulinastatin treatment could result in protective effects for sepsis. " 07/01/2013 - "The aim of the present study was to determine the efficacy of ulinastatin (UTI) for the treatment of sepsis and to investigate the associated molecular mechanisms. " 03/01/2008 - "Urinary trypsin inhibitor treatment ameliorates acute lung and liver injury resulting from sepsis in a rat model." 12/01/2015 - "Randomized clinical trials on treatment of sepsis with the combination of ulinastatin and Tα1, compared with placebo, were reviewed. "
3.	Reperfusion Injury 03/01/1999 - "Protective effects of ulinastatin against ischemia-reperfusion injury." 12/01/2011 - "Ulinastatin improved cardiac function and reduced infarct size after regional ischemia/reperfusion injury. " 07/01/2011 - "Addition of ulinastatin to preservation solution promotes protection against ischemia-reperfusion injury in rabbit lung." 12/01/2011 - "Ulinastatin showed a myocardial protective effect after regional ischemia/reperfusion injury in an in vivo rat heart model. " 12/01/2011 - "Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model."
4.	Ischemia 07/22/2004 - "Ulinastatin greatly improved renal function and provides remarkable protection on renal ultrastructure after ischemia-reperfusion of kidney in rats." 09/01/1989 - "2) In canine experimental model of renal ischemia, ulinastatin significantly improved urine volume and urine NAG levels. " 11/01/1998 - "Evidence of neutrophil involvement in the protective effects of urinary trypsin inhibitor against ischemia reperfusion in vitro." 08/01/2015 - "Ulinastatin treatment inhibited ischemia-induced apoptosis by suppressing apoptosis-associated molecules, and thus ameliorated ischemia-induced short-term memory impairment. " 03/01/2014 - "The aim of this paper was to investigate the mechanism of ulinastatin's protection of lung from injury caused by lower limb ischemia-reperfusion in a rat model. "
5.	Burns 11/02/2005 - "[Protective effects of ulinastatin against multiple organic damage after severe burn injury: experimental and clinic studies]." 01/01/2006 - "Urinastatin has protective effects on multiple organs in severe burn injury." 01/01/2006 - "To investigate the protective effects of urinastatin on organ function in severe burn. " 01/01/2006 - "[Protective effects of urinastatin on organ function in patients with severe burn]." 08/01/2008 - "The clinical and experimental data showed that ulinastatin relieved myocardial damage from severe burn. "

Related Drugs and Biologics

1.	urinastatin (MR 20)
2.	Protease Inhibitors (Protease Inhibitor)
3.	Leukocyte Elastase (Neutrophil Elastase)
4.	Trypsin
5.	thymalfasin
6.	Oxygen
7.	Anti-Bacterial Agents (Antibiotics)
8.	Cytokines
9.	Somatostatin (Somatotropin Release-Inhibiting Factor)
10.	Phosgene

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)
3.	Ligation
4.	Immunomodulation
5.	Liver Transplantation