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palmitoyl CoA oxidase

in peroxisomes; forms hydrogen peroxide

Also Known As:

palmitoyl coenzyme A oxidase; palmityl CoA oxidase

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - palmitoyl CoA oxidase: 12

Experts

1.	Daniel, F Bernard: 1 article (01/2008)
2.	DeAngelo, Anthony B: 1 article (01/2008)
3.	George, Michael H: 1 article (01/2008)
4.	Wong, Diana M: 1 article (01/2008)
5.	Ashby, John: 1 article (04/2002)
6.	Elcombe, Clifford R: 1 article (04/2002)
7.	Foster, John R: 1 article (04/2002)
8.	Hasmall, Susan: 1 article (04/2002)
9.	Kimber, Ian: 1 article (04/2002)
10.	Odum, Jenny: 1 article (04/2002)

Related Diseases

1.	Hepatomegaly 12/01/2000 - "Treating rats (DNS-X in the diet at 0.3% w/w) for 6 d leads to a hepatomegaly and a marked increase in liver peroxisomal palmitoyl-CoA oxidase activity. " 04/01/1996 - "Zileuton pretreatment caused hepatomegaly and elevated liver peroxisomal KCN-insensitive palmitoyl CoA oxidase activity in a dose-dependent manner. " 12/17/1990 - "In the livers a hepatomegaly, an induction of cytochrome P-450 IVA1 and induction of the activity of palmitoyl-CoA oxidase and carnitine acetyl-CoA transferase was found to be 180%, 1080%, 1300% and 1700% of control values, respectively. " 06/01/1987 - "At hypolipidemic doses the compound causes no hepatomegaly, no induction of peroxisomal catalase and palmitoyl-CoA oxidase activities, no smooth endoplasmic reticulum proliferation and no induction of microsomal cytochrome P-450 and of cytochrome P-450 dependent enzyme activities: aminopyrine (aminophenazone) N-demethylase, aniline hydroxylase, zoxazolamine hydroxylase and hexobarbital oxidase. "
2.	Body Weight (Weight, Body) 05/01/1987 - "Dose-related increases in organ (liver and kidney) weight/body weight ratios, individual cell necrosis in the liver, and hepatic microsomal NADPH cytochrome c reductase and peroxisomal palmitoyl-CoA oxidase and catalase activities were found in both the dosed-fed and gavage groups. " 01/01/1991 - "Treatment of rats with 1.0% dioxane in the drinking water for 5 days yielded no increase in liver/body weight nor induction of palmitoyl CoA oxidase, indicating that dioxane does not fit into the class of peroxisomal proliferating carcinogens. " 12/01/1987 - "Five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (2 g/kg) given to rats on Days 2-6, 6-10, or 14-18 of lactation caused significant decreases in body weight and increases in hepatic peroxisomal enzymes palmitoyl CoA oxidase and carnitine acetyltransferase in the dams and their suckling pups. "
3.	Neoplasms (Cancer) 01/01/2008 - "A TCA-induced increase in liver palmitoyl CoA oxidase activity, a marker of peroxisome proliferation, correlated with tumor induction. "
4.	Necrosis 05/01/1987 - "Dose-related increases in organ (liver and kidney) weight/body weight ratios, individual cell necrosis in the liver, and hepatic microsomal NADPH cytochrome c reductase and peroxisomal palmitoyl-CoA oxidase and catalase activities were found in both the dosed-fed and gavage groups. "
5.	Liver Neoplasms (Liver Cancer) 06/15/1989 - "To evaluate the possibility that the promotional activity of WY-14,643 was more effective at a later stage in hepatocarcinogenesis, rats receiving a dose of DEN and then phenobarbital in the diet for 11 wk were changed to a diet containing WY-14,643 for an additional 11 or 43 wk. However, WY-14,643 feeding from wk 11 to 22 caused a reduction in volume density of ATPase-deficient foci relative to the volume density of foci at 11 wk. In addition, feeding WY-14,643 from wk 11 to 54 caused similar yields of hepatic neoplasms whether or not phenobarbital was fed for the initial 11 wk. WY-14,643 induced hepatic peroxisome proliferation as indicated by palmitoyl CoA oxidase activity regardless of prior treatment with DEN and/or phenobarbital. "

Related Drugs and Biologics

1.	Enzymes
2.	Cytochrome P-450 Enzyme System (Cytochrome P450)
3.	Catalase
4.	Carnitine O-Acetyltransferase
5.	Drinking Water
6.	Peroxisome Proliferators
7.	Triiodothyronine (Liothyronine)
8.	Thyroxine (Levothyroxine)
9.	Thyrotropin (Thyroid-Stimulating Hormone)
10.	Phenobarbital (Luminal)