rotenolone

decomposition product of rotenone; RN given refers to (2 alpha,6a beta,12a beta)-isomer

Also Known As:

12-hydroxyrotenone; 6 alpha(beta),12 alpha(beta)-rotenolone; rotenolone, (2R-(2alpha,6aalpha,12aalpha))-isomer; rotenolone, (2R-(2alpha,6aalpha,12abeta))-isomer; rotenolone, (2R-(2alpha,6abeta,12aalpha))-isomer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kingston, David G I: 2 articles (09/2010 - 03/2004)
2.	Rasamison, Vincent E: 2 articles (09/2010 - 03/2004)
3.	Brodie, Peggy J: 1 article (09/2010)
4.	Callmander, Martin W: 1 article (09/2010)
5.	Harinantenaina, Liva: 1 article (09/2010)
6.	Rakotobe, Etienne: 1 article (09/2010)
7.	Randrianaivo, Richard: 1 article (09/2010)
8.	Randrianasolo, Sennen: 1 article (09/2010)
9.	Shen, Yongchun: 1 article (09/2010)
10.	Slebodnick, Carla: 1 article (09/2010)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 03/01/2004 - "All the isolated compounds were tested for cytotoxicity against the A2780 human ovarian cancer cell line; rotenolone and rotenone were the most potent compounds isolated, with IC(50) values of 0.5 and 0.7 microg/mL, respectively." 09/24/2010 - "Compounds 2-5 displayed moderate antiproliferative activity against the A2780 human ovarian cancer cell line, and rotenolone also showed micromolar antiproliferative activity toward the breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines."
2.	Prostatic Neoplasms (Prostate Cancer) 09/24/2010 - "Compounds 2-5 displayed moderate antiproliferative activity against the A2780 human ovarian cancer cell line, and rotenolone also showed micromolar antiproliferative activity toward the breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines."
3.	Colonic Neoplasms (Colon Cancer) 09/24/2010 - "Compounds 2-5 displayed moderate antiproliferative activity against the A2780 human ovarian cancer cell line, and rotenolone also showed micromolar antiproliferative activity toward the breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines."
4.	Breast Neoplasms (Breast Cancer) 09/24/2010 - "Compounds 2-5 displayed moderate antiproliferative activity against the A2780 human ovarian cancer cell line, and rotenolone also showed micromolar antiproliferative activity toward the breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines."

Related Drugs and Biologics

1.	Rotenone