3- ((3- cholamidopropyl)dimethylammonium)- 1- propanesulfonate (CHAPS)

a surfactant; structure given in first source

Also Known As:

CHAPS; 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt; 3-(3-cholamidopropyl)dimethylammoniumpropane sulfonate; cholic acid sulfobetaine1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt; 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt

Networked: 65 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Bile Acids and Salts: 11432
      - Cholic Acids: 14
        3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate: 65
    - Cholanes
      - Cholic Acids: 14
        3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate: 65

Experts

1.	Ganz, David A: 5 articles (01/2022 - 12/2015)
2.	Mittman, Brian S: 5 articles (01/2022 - 12/2015)
3.	Siebens, Hilary C: 5 articles (01/2022 - 12/2015)
4.	Barry, Frances: 4 articles (01/2022 - 01/2019)
5.	Cheng, Eric M: 4 articles (01/2022 - 01/2019)
6.	Connor, Karen I: 4 articles (01/2022 - 01/2019)
7.	Vickrey, Barbara G: 4 articles (01/2022 - 01/2019)
8.	McNeese-Smith, Donna K: 3 articles (01/2022 - 08/2020)
9.	Edwards, Lisa K: 3 articles (12/2020 - 01/2019)
10.	McGowan, Michael G: 3 articles (12/2020 - 01/2019)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/24/2022 - "A recent multisite randomized trial of a proactive, telephone-based, nurse-led care management intervention - Care Coordination for Health Promotion and Activities in Parkinson's Disease (CHAPS) - demonstrated improved PD care quality. " 12/02/2020 - "A recent nurse-led proactive care management intervention, Care Coordination for Health Promotion and Activities in Parkinson Disease (CHAPS), improved care quality when compared to usual care in a randomized controlled trial. " 08/10/2020 - "A recent nurse-led, telephone-administered 18-month intervention, Care Coordination for Health Promotion and Activities in Parkinson's Disease (CHAPS), was tested in a randomized controlled trial and improved care quality. " 12/15/2015 - "Study protocol of "CHAPS": a randomized controlled trial protocol of Care Coordination for Health Promotion and Activities in Parkinson's Disease to improve the quality of care for individuals with Parkinson's disease." 01/24/2022 - "Implementation fidelity of a nurse-led RCT-tested complex intervention, care coordination for health promotion and activities in Parkinson's disease (CHAPS) in meeting challenges in care management."
2.	Prostatitis 01/01/1998 - "The efficacy of complex homeopathic remedies produced by firm "Heel" is established in the treatment of chronic prostatitis in participants of an accident liquidation on the CHAPS."
3.	Myocardial Infarction 01/12/2016 - "In a substudy of Carlscrona Heart Attack Prognosis Study (CHAPS) of 5292 patients admitted to the coronary care unit, we identified 908 patients aged 30-74 years, who at discharge had received the diagnosis of either MI (527) or UA (381). " 04/01/1999 - "Forty-nine patients with predischarge left ventricular ejection fraction <45% after acute myocardial infarction were evaluated in a double-blind, randomized, placebo-controlled, parallel group study (selected from the database of the Carvedilol Heart Attack Pilot Study: CHAPS). "
4.	Neuroblastoma 05/01/2014 - "The zwitterionic detergent CHAPS was used to solubilize the human mu-opioid receptor (hMOR) from SH-SY5Y neuroblastoma cells and recombinant hMOR-CHO (CHO-T7-hMOR) and hMOR-SH-SY5Y (SH-SY5Y-T7-hMOR) cell membranes. " 12/15/1994 - "Previous work has demonstrated that crosslinking of [125I]AngII to CHAPS solubilized angiotensin Type 2 receptors (AT2) in N1E-115 neuroblastoma cells identifies two radiolabeled proteins of 110 and 66 kDa. Similarly, affinity purification of AT2 receptors using AngII yields two proteins of 110 and 66 kDa. In the present study, anti-AT2 receptor antisera were used to examine the relationship between these two proteins. " 11/01/1992 - "5-Hydroxytryptamine3 (5-HT3) receptor-type binding sites were solubilised from NG108-15 mouse neuroblastoma x rat glioma hybrid cells using five different detergents [n-octyl-beta-D-glucoside, Triton X-100, 3-[3-(cholamidopropyl)dimethylammonio]-1-propanesulphonate (CHAPS), sodium cholate, and deoxycholate] and the solubilisation efficiencies compared. " 11/01/1991 - "Angiotensin II (Ang-II) receptors were solubilized from differentiated N1E-115 neuroblastoma cell membranes with the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS), whereas other detergents, such as digitonin, sodium cholate, and Triton X-100, were much less effective. "
5.	Inflammation (Inflammations) 01/01/2007 - "In this study, we addressed the question of PI3K involvement in the production of IL-1beta and sIL-1Ra in monocytes activated by cellular contact with stimulated T cells (mimicked by CHAPS-solubilized membranes of stimulated T cells (CE(sHUT))), and a crude preparation of LPS, to compare stimuli relevant to chronic/sterile and acute/infectious inflammation, respectively. " 07/01/2008 - "Here we show that in contrast with PI3Kalpha, beta and gamma, PI3Kdelta accounts for most of the PI3K-dependent signaling ruling the production of IL-1beta, IL-6, TNF and sIL-1Ra in monocytes activated by cellular contact with stimulated T cells (mimicked by CHAPS-solubilized membranes of stimulated T cells, CE sHUT) and lipopolysaccharides (LPS); the latter stimuli being relevant to chronic/sterile and acute/infectious inflammation, respectively. "

Related Drugs and Biologics

1.	Materia Medica (Homeopathic Remedies)
2.	Proteins (Proteins, Gene)
3.	Immune Sera (Antisera)
4.	Angiotensins
5.	Carvedilol (Coreg)
6.	Detergents (Detergent)
7.	propylsulfonic acid
8.	Buffers
9.	Octoxynol (Triton X 100)
10.	Urea (Carbamide)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Intra-Arterial Infusions