androsterone glucuronide

RN given refers to (3alpha,5alpha)-isomer

Also Known As:

(3alpha,5alpha)-17-oxoandrostan-3-yl beta-D-glucopyranosiduronic acid; androsterone glucosiduronate; androsterone glucuronide, (3beta,5alpha)-isomer; androsterone glucuronide, (beta-D)-isomer; androsterone glucuronide, sodium salt, (3alpha,5alpha)-isomer; androsterone glucuronide, sodium salt, (3alpha,5beta)-isomer; etiocholanolone glucuronide

Networked: 22 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stanczyk, F Z: 2 articles (10/2002 - 05/2001)
2.	Al-Jaber, Hend: 1 article (01/2021)
3.	Al-Mansoori, Layla: 1 article (01/2021)
4.	Albagha, Omar: 1 article (01/2021)
5.	Diboun, Ilhame: 1 article (01/2021)
6.	Elrayess, Mohamed A: 1 article (01/2021)
7.	Anderson, Garnet L: 1 article (10/2019)
8.	Brinton, Louise A: 1 article (10/2019)
9.	Falk, Roni T: 1 article (10/2019)
10.	Geczik, Ashley M: 1 article (10/2019)

Related Diseases

1.	Hirsutism 03/01/1990 - "Androsterone glucuronide levels (nmol/l; mean +/- SD) were significantly higher (P less than 0.025) in women with mild idiopathic hirsutism (IH) (185 +/- 91), severe IH (173 +/- 97), and hirsute women with polycystic ovarian syndrome (PCO) (178 +/- 102) than in normal women (110 +/- 26). " 03/01/1990 - "To investigate the significance of serum androsterone glucuronide, we developed a direct radioimmunoassay for this compound and measured its levels in normal women, women with mild or severe idiopathic hirsutism (IH), hirsute women with polycystic ovarian syndrome (PCO), and non-hirsute obese women. " 01/01/1993 - "The fact that its levels were not elevated in hirsutism, although those of other adrenal androgens and androgen metabolites (androstanediol glucuronide and androsterone glucuronide) were, suggests that variations in sulfotransferase activity or metabolic clearance of Andros-S may be important determinants of serum Andros-S levels. " 06/01/1992 - "As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase activity, we measured, as parameters of 5 alpha-reductase activity, plasma levels of 5 alpha-androstane-3 alpha,17 beta-diol glucuronide (ADG) and androsterone glucuronide (ADTG) as well as their precursor levels in obese women without hirsutism, obese hirsute women, non-obese hirsute women, and non-obese, non-hirsute women. "
2.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 03/01/1990 - "Androsterone glucuronide levels (nmol/l; mean +/- SD) were significantly higher (P less than 0.025) in women with mild idiopathic hirsutism (IH) (185 +/- 91), severe IH (173 +/- 97), and hirsute women with polycystic ovarian syndrome (PCO) (178 +/- 102) than in normal women (110 +/- 26). " 03/01/1990 - "To investigate the significance of serum androsterone glucuronide, we developed a direct radioimmunoassay for this compound and measured its levels in normal women, women with mild or severe idiopathic hirsutism (IH), hirsute women with polycystic ovarian syndrome (PCO), and non-hirsute obese women. " 05/19/2017 - "Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome." 12/01/1989 - "In hirsute compared with nonhirsute patients with polycystic ovarian syndrome, serum 3 alpha-diol glucuronide was increased by the smallest amount (32%), followed by androsterone sulfate (38%), 3 alpha-diol sulfate (59%), and androsterone glucuronide with the largest increase (134%). "
3.	Acne Vulgaris 10/01/2002 - "Serum androsterone glucuronide (AoG) is a metabolite of circulating androgens under the influence of 5alpha-reductase activity and has been shown to be particularly elevated in women with acne. " 11/01/2002 - "In acne patients it is still controversial if 3alpha-androstanediol glucuronide or androsterone glucuronide could serve as suitable serum markers for measuring androgenicity. " 05/01/1994 - "It is concluded that 13-cis-RA therapy in men with severe nodulocystic acne did not alter gonadal or adrenal functions, but it did induce 1) a highly significant decrease in 5 alpha-dihydrotestosterone formation by skin biopsies; 2) significant decreases in serum 5 alpha-dihydrotestosterone, androsterone glucosiduronate, and 5 alpha-androstan-3 alpha, 17 beta-diol glucosiduronate; and, finally, 3) deviation of the liver androgen 5 alpha- to 5 beta-reduction pathway. "
4.	Breast Cyst 04/01/1998 - "High levels of androsterone glucuronide and androstane-3alpha,17beta-diol glucuronide found in the human prostate, breast cyst fluid and ovary follicular fluid suggest that glucuronidation of 5alpha-reduced C19 steroids occurs in these tissues. " 01/01/1990 - "The present report deals with the concentrations of C-21, C-19 and C-18 steroids as well as steroid glucuronides, namely androstane-3 alpha,17 beta-diol glucuronide, androsterone glucuronide, estradiol glucuronide, and estrone glucuronide (E1-G) in breast cyst fluid (BCF). "
5.	Prostatic Neoplasms (Prostate Cancer) 05/01/2001 - "To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. " 08/01/1996 - "After a surveillance period of more than 20 years, 141 tissue-confirmed incident cases of prostate cancer were identified, and their stored sera and those of 141 matched controls were assayed for total testosterone, free testosterone, dihydrotestosterone, 3-alpha-androstanediol glucuronide, androsterone glucuronide, and androstenedione. "

Related Drugs and Biologics

1.	Glucuronides
2.	Androgens
3.	Sulfotransferases
4.	Testosterone (Sustanon)
5.	Steroids
6.	Dihydrotestosterone (Androstanolone)
7.	Dehydroepiandrosterone Sulfate
8.	Sulfates (Sulfates, Inorganic)
9.	Androsterone
10.	androsterone sulfate

Related Therapies and Procedures

1.	Therapeutics