HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

poly-N(5)-(2-hydroxyethyl)glutamine

Also Known As:

PHEG; poly-alpha-(N(5)-(2-hydroxyethyl)-L-glutamine)

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - poly-N(5)-(2-hydroxyethyl)glutamine: 3

Related Diseases

1.	Cardiotoxicity 01/01/1991 - "On the other hand, a decrease in total toxicity and cardiotoxicity resulting from the linkage of DNR and PHEG, the therapeutic efficacy being preserved, stimulates the efforts to find a suitable polymer carrier of anthracyclines without more serious side-effects."
2.	Neoplasms (Cancer) 02/01/1999 - "The results indicate that the PHEG-Gly-Phe-Ala-Leu-PDM conjugate is a promising candidate for cancer treatment." 01/01/1984 - "The injections of 3.2 mg (equivalent ara-C per kg) of ara-C:PHEG showed a moderate antitumor activity with an ILS of 113% which was similar to the ILS (119%) found when unconjugated ara-C (400 mg/kg) was used to treat tumor-bearing mice. "
3.	Plasmacytoma 01/01/1991 - "The linkage of DNR and PHEG did not markedly change the therapeutic activity in three murine hemoblastoses--plasmacytoma MOPS 406, leukemia P388 and hemoblastosis La. "
4.	Leukemia P388 01/01/1991 - "The linkage of DNR and PHEG did not markedly change the therapeutic activity in three murine hemoblastoses--plasmacytoma MOPS 406, leukemia P388 and hemoblastosis La. "
5.	Body Weight (Weight, Body) 02/01/1999 - "The PHEG-Gly-Phe-Ala-Leu-PDM conjugate, which is rapidly degraded by lysosomal and tumour-associated enzymes also showed a decreased systemic toxicity in vivo and could be administered at a dose of 8 mg PDM/kg body weight intravenously, compared with just 2 mg/kg for free PDM. "

Related Drugs and Biologics

1.	Anthracyclines
2.	Polymers
3.	Enzymes
4.	Cytarabine (Cytosar-U)
5.	glycylphenylalanine
6.	morpholinopropane sulfonic acid (MOPS)

Related Therapies and Procedures

1.	Injections