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milbemycin (moxidectin)

family of macrolide antibiotics with insecticidal & acaricidal activity; RN given refers to cpd with unknown MF; milbemectin is a mixture of milbemycins A3 and A4; structure in first source; moxidectin (CL 301,423) is milbemycin B

Also Known As:

moxidectin; 5-hydroxymilbemycin beta7; CL 301,423; CL 301423; Cydectin; milbemectin; milbemycin A3; milbemycin A4; milbemycin B; milbemycin D; milbemycin alpha1; milbemycin alpha10; milbemycin alpha11; milbemycin alpha13; milbemycin alpha14; milbemycin alpha15; milbemycin alpha2; milbemycin alpha3; milbemycin alpha4; milbemycin alpha5; milbemycin alpha6; milbemycin alpha7; milbemycin alpha8; milbemycin alpha9; milbemycin beta1; milbemycin beta12; milbemycin beta2; milbemycin beta3; milbemycins

Networked: 226 relevant articles (78 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Traversa, Donato: 8 articles (10/2015 - 06/2005)
2.	Schaper, Roland: 8 articles (08/2013 - 06/2008)
3.	Di Cesare, Angela: 5 articles (10/2015 - 08/2009)
4.	Pampurini, Fabrizio: 5 articles (01/2015 - 08/2009)
5.	Genchi, Claudio: 5 articles (08/2013 - 12/2002)
6.	Reinemeyer, C R: 4 articles (12/2015 - 03/2000)
7.	Bowman, Dwight D: 4 articles (06/2015 - 01/2002)
8.	Genchi, Marco: 4 articles (08/2013 - 12/2002)
9.	Yazwinski, T A: 4 articles (07/2013 - 12/2004)
10.	Rojo-Vázquez, F A: 4 articles (03/2013 - 12/2001)

Related Diseases

1.	Infection 04/15/2006 - "Study results demonstrate QG, administered to horses with naturally acquired endoparasite infections at a dosage of 0.4 mg moxidectin/kg b.w., was highly effective against a broad range of equine parasitic infections." 11/01/2004 - "A single SC injection of a sustained-release formulation of moxidectin was effective in providing protection against heartworm infection after 12 months in dogs. " 11/01/2004 - "To evaluate the efficacy of a single injection of a sustained-release formulation of moxidectin in preventing heartworm (Dirofilaria immitis) infection for 12 months in dogs. " 01/01/2015 - "A timely administration of an anthelmintic (mostly moxidectin) showed to be effective in treating the infection in those dogs (i.e. " 03/01/2000 - "In addition to demonstrating the boticidal efficacy of moxidectin, this trial illustrated that gastroscopy/duodenoscopy is a feasible method for confirming infections with different species of bot larvae in the horse."
2.	Nematode Infections 03/01/1992 - "The efficacy of moxidectin, a new endectocide against natural nematode infections, was evaluated. " 11/25/2005 - "The efficacy of 0.5% moxidectin pour-on in cows with naturally acquired nematode infections was evaluated. " 11/25/2005 - "Efficacy of moxidectin 0.5% pour-on against naturally acquired nematode infections in cattle in the Mexican tropics." 01/15/1998 - "Efficacy of moxidectin 2% equine gel against natural nematode infections in ponies." 10/15/1996 - "The efficacy of 0.5% moxidectin pour-on at two dosages was evaluated in 30 cattle with naturally acquired gastrointestinal nematode infections. "
3.	Body Weight (Weight, Body) 10/01/1998 - "The pour-on formulation of moxidectin, at 500 microg/kg body weight, is highly effective against mature and immature lungworms and abomasal nematodes in wapiti hybrid deer and equally effective in red deer." 02/01/1995 - "Treatment with moxidectin in single doses of 300, 400, or 500 micrograms/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive following placebo treatment. " 12/01/2014 - "The plasma kinetic profile of moxidectin (MXD) in ewes during the last third of pregnancy was studied after the subcutaneous dose of 0.2 mg/kg of body weight (bw). " 08/01/2011 - "The dosage was one pipet per ferret (designed for cats weighing up to 4 kg, corresponding to a dose of moxidectin ranging from 2.2 to 5 mg/kg body weight) two or three times at 14-days intervals (at D0, D14 and possibly D28 depending on the parasitological examination of the ears at D28). " 07/20/2007 - "The bioavailability of this long-acting formulation of moxidectin is similar to that registered after subcutaneous administration of moxidectin in cattle at 0.2 mg kg(-1) body weight. "
4.	Mite Infestations (Mange) 01/01/2005 - "A single dose of topical moxidectin as an effective treatment for murine acariasis due to Myocoptes musculinus." 11/01/1998 - "We report the efficacy of moxidectin (SC, 200 mcg/kg, b.w.) in a repeated treatment program of 7-10 d, which is currently used for mange control in these ruminants." 01/01/2005 - "To the authors' knowledge, this is the first report of topical moxidectin as a treatment for murine acariasis." 06/30/1999 - "The use of moxidectin for the prevention and treatment of psoroptic mange (scab) in sheep." 11/02/1996 - "Treatment and control of psoroptic mange (sheep scab) with moxidectin."
5.	Scabies (Sarcoptic Mange) 01/01/2000 - "Moxidectin was found to be effective against ovine sarcoptic mange, when given twice; the percentage reduction of mites was 100% (p < 0.0001) and the skin lesions disappeared completely (p = 0.0001). " 12/10/2011 - "Efficacy of long-acting moxidectin against sarcoptic mange in naturally infested sheep." 01/01/2000 - "Efficacy of moxidectin against sarcoptic mange and effects on milk yield of ewes and growth of lambs." 01/01/2011 - "Moxidectin efficacy in a goat herd with chronic and generalized sarcoptic mange." 11/10/2000 - "Forty-one dogs suffering from sarcoptic mange were treated with 0.2-0.25mg/kg moxidectin either orally or subcutaneously every week for three to six times. "

Related Drugs and Biologics

1.	imidacloprid
2.	Ivermectin (Mectizan)
3.	doramectin
4.	milbemycin (moxidectin)
5.	Tablets
6.	milbemycin oxime (Interceptor)
7.	4''-epiacetylamino-4''-deoxyavermectin B1 (eprinomectin)
8.	fluphenacur (lufenuron)
9.	Fenbendazole
10.	Propoxur (Baygon)

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)
3.	Subcutaneous Injections
4.	Microspheres (Microsphere)
5.	Withholding Treatment