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phorbol ester receptor
Also Known As:
phorboid receptor; phorbol dibutyrate receptor; phorbol ester receptors; phorbol myristate acetate receptor; receptor, phorbol esters; tetradecanoyl phorbol receptor
Networked:
26
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Transferases: 6589
Phosphotransferases: 42769
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases: 9677
Protein Serine-Threonine Kinases: 3588
Protein Kinase C: 5856
phorbol ester receptor: 26
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Drug Receptors: 61
phorbol ester receptor: 26
Intracellular Signaling Peptides and Proteins: 32
Protein Serine-Threonine Kinases: 3588
Protein Kinase C: 5856
phorbol ester receptor: 26
Experts
1.
Kazanietz, M G
: 2 articles (11/2001 - 05/2000)
2.
Kazanietz, Marcelo G
: 1 article (12/2005)
3.
Barry, O P
: 1 article (11/2001)
Related Diseases
1.
Cardiomegaly (Heart Hypertrophy)
10/01/1986 - "
Cardiac hypertrophy is accompanied by a significant reduction in the number of phorbol ester receptors on enzymatically dissociated myocytes with no changes in their affinities.
"
2.
GM1 Gangliosidosis (Gangliosidosis GM1)
01/01/1991 - "
These studies demonstrate the presence of highly specific, homogenous, single type phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis which are qualitatively and quantitatively similar to normal cat brain.
"
01/01/1991 - "
Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis.
"
3.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
09/01/1987 - "
Normal keratinocytes, SV40-transformed keratinocytes (SVK14), and various squamous carcinoma cell (SCC) lines have been used as an in vitro model system to study the properties of phorbol ester receptor and protein kinase C expression during keratinocyte differentiation.
"
4.
Neoplasms (Cancer)
01/01/1983 - "
The evidence for the multistage nature of tumor promotion in vivo and for multiple subclasses of phorbol ester receptors in vitro argues that multiple mechanisms of tumor promotion exist.
"
02/01/1993 - "
The presence of tumor-promoting phorbol ester receptors in rat prostate was investigated by studying the binding of phorbol diester 12,13-dibutyrate (PDBu) in both soluble and particulate subcellular fractions.
"
12/30/2005 - "
The discovery of the chimaerins and other "non-kinase" phorbol ester receptors has major implications in the design of agents for cancer therapy.
"
03/01/1991 - "
The phorbol ester receptor (PER), which is believed to be identical to protein kinase C (PKC), has been implicated in the control of the sensitivities of tumor cells to certain forms of cancer chemotherapy.
"
11/01/1999 - "
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
"
5.
Leukemia
08/01/1984 - "
Prevention of phorbol ester receptor down modulation in human myeloblastic leukemia ML-1 cells by differentiation-stimulating serum components.
"
12/01/1983 - "
The nature of phorbol ester receptors in intact Friend erythroid leukemia cells (FLC) was examined by utilizing 3H-phorbol dibutyrate (3H-PDBu).
"
04/25/1987 - "
1,25-Dihydroxyvitamin D3 regulation of phorbol ester receptors in HL-60 leukemia cells.
"
03/01/1986 - "
Our research indicates that bryostatin, a macrocyclic lactone that binds to the phorbol ester receptor in human polymorphonuclear leukocytes, also binds to this receptor in the human promyelocytic leukemia cell line, HL-60.
"
06/01/1985 - "
Specificities of acylglycerols and phospholipids for interaction with phorbol ester receptor on Friend leukemia cells.
"
Related Drugs and Biologics
1.
Protein Kinase C
2.
Phorbol Esters
3.
Phosphotransferases (Kinase)
4.
Phospholipids (Phosphatides)
5.
Isoenzymes
6.
Interleukin-2 (IL2)
7.
Bryostatins
8.
Thapsigargin
9.
Steroid Receptors (Steroid Receptor)
10.
Quercetin
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)
2.
Therapeutics