N(delta)- (N- methyl- N- nitrosocarbamoyl)- L- ornithine (MNCO)

08/01/1980 - "The duration of these studies was limited by toxicity and carcinogenicity to six months in a high dose group which received 1 mmole MNCO/kg IP weekly for 6 months and to 1 year in a group which received 0.33 mmole/kg. In the latter group the incidence of neoplasms was breast, 40%; skin, 52%; kidney, 81%; pancreas, 19%; and ear duct, 4%. "
10/01/2023 - "The combination of EGCG and MnCO can significantly minimize the thermo-resistance of tumors and improve PTT sensitivity. "
10/01/2023 - "Upon near-infrared (NIR) irradiation, the photothermal effect of PDA can kill tumor cells and allow for the controlled drug release of MnCO and EGCG. "
01/01/2021 - "MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. "
01/01/2020 - "Especially, H2O2 in tumor sites and the photothermal effect of MTO could trigger MnCO to generate CO, which made cancer cells more sensitive to MTO and significantly alleviated cell resistance. "

06/01/1984 - "Azaserine and MNCO have induced acinar cell carcinomas in rats. "
12/01/1983 - "Carcinomas of the pancreas, stomach, and breast, as well as mesotheliomas and ovarian stromal tumors, were induced in Syrian golden hamsters treated with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), which has previously been shown to cause pancreatic acinar cell carcinomas in rats. "

12/01/1983 - "Experimental induction of pancreatic carcinomas in the hamster with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine."
12/01/1979 - "Syrian golden hamsters were treated with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), a nitrosourea amino acid, which has induced a high incidence of breast, kidney and skin neoplasms and a low incidence of pancreatic carcinoma in rats. "

12/01/1979 - "MNCO induced a few breast and skin carcinomas, and a high incidence of foci of atypical acinar cells and of focal ductular abnormalities in the exocrine pancreas. "
12/01/1983 - "Carcinomas of the pancreas, stomach, and breast, as well as mesotheliomas and ovarian stromal tumors, were induced in Syrian golden hamsters treated with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), which has previously been shown to cause pancreatic acinar cell carcinomas in rats. "

12/01/1979 - "Syrian golden hamsters were treated with N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), a nitrosourea amino acid, which has induced a high incidence of breast, kidney and skin neoplasms and a low incidence of pancreatic carcinoma in rats. "