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S-methylisothiopseudouronium

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inhibits nitric oxide synthase; structure in first source

Also Known As:

S-methyl isothiourea; S-methylisothiopseudouronium monohydrobromide; S-methylisothiopseudouronium monohydrochloride; S-methylisothiopseudouronium monohydroiodide; S-methylisothiopseudouronium mononitrate; S-methylisothiopseudouronium phosphate (1:1); S-methylisothiopseudouronium sulfate; S-methylisothiopseudouronium sulfate (1:1); S-methylisothiopseudouronium sulfate (2:1); S-methylisothiourea; S-methylisothiourea sulfate; S-methylisothiouronium; S-methylthiopseudouronium iodide; S-methylthiourea

Networked: 77 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Urea: 9142
  - Thiourea: 242
    - Isothiuronium: 8
      - S-methylisothiopseudouronium: 77
- Sulfur Compounds: 135
  - Thiourea: 242
    - Isothiuronium: 8
      - S-methylisothiopseudouronium: 77

Experts

1.	Kumar, Dinesh: 7 articles (10/2014 - 03/2005)
2.	Chen, Lee-Wei: 7 articles (01/2013 - 04/2002)
3.	Hsu, Ching-Mei: 7 articles (01/2013 - 04/2002)
4.	Wang, Jyh-Seng: 6 articles (04/2005 - 04/2002)
5.	Chen, Jin-Shyr: 5 articles (04/2005 - 08/2003)
6.	Tandan, Surendra K: 4 articles (10/2014 - 01/2010)
7.	Balaganur, Venkanna: 3 articles (10/2014 - 02/2013)
8.	Yasar, Mehmet: 3 articles (09/2011 - 05/2003)
9.	Korkmaz, Ahmet: 3 articles (09/2011 - 01/2004)
10.	Chen, Hsing I: 3 articles (11/2009 - 05/2005)

Related Diseases

1.	Burns 12/01/2006 - "Fifty-six male Wistar rats were enrolled in the study and randomized into control( C, n = 8,without treatment) , burn ( B, n = 24) , and S-methylisothiourea( SMT, n = 24) groups. " 04/01/2005 - "Inhibition of iNOS with S-methylisothiourea was impaired in wound healing in caustic esophageal burn." 12/01/2004 - "Administration of hypertonic saline at 8 hrs after burn and S-methylisothiourea injection also significantly attenuated the bacterial translocation to mesenteric lymph nodes and villi sloughing. " 12/01/2004 - "To the contrary, burn + S-methylisothiourea rats with hypertonic saline injection at 4 or 8 hrs after burn showed an improvement of gut barrier function compared with burn + S-methylisothiourea + 7.5 mg/kg saline and burn + S-methylisothiourea + 50 mL/kg saline rats. " 11/01/2003 - "In experiment 2, intraperitoneal S-methylisothiourea sulfate (7.5 mg/kg) was given immediately after burn to rats from different groups, as in experiment 1 (SMT groups). "
2.	Osteoarthritis 06/01/2007 - "To investigate the efficacy of S-methylisothiourea (SMT) for treatment of temporomandibular joint osteoarthrosis (TMJOA) of goats. " 06/01/2007 - "[Animal experimental study of intra-articular injection of S-methylisothiourea for treatment of temporomandibular joint osteoarthrosis]." 07/01/2014 - "Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis." 10/01/2014 - "The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. " 10/01/2014 - "Effect of S-methylisothiourea, an inducible nitric oxide synthase inhibitor, in joint pain and pathology in surgically induced model of osteoarthritis."
3.	Lung Injury 08/01/2008 - "Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats." 06/01/2012 - "We have investigated whether S-methylisothiourea protects different pulmonary aspiration gastrointestinal decontamination agent-induced lung injury in rats. " 01/01/2013 - "S-methylisothiourea treatment significantly decreased P aeruginosa infection with thermal injury pretreatment-induced lung injury, blood bacterial counts, pulmonary IL-1β expression, and mortality in Tnfrsf1a(-/-) mice. " 08/01/2008 - "The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats. " 03/15/1998 - "We developed an acute lung injury dog model by injecting LPS, and examined the effects of selective iNOS inhibitors, aminoguanidine (AG) and S-methylisothiourea sulfate (SMT), on the LPS-induced lung injury. "
4.	Septic Shock (Toxic Shock Syndrome) 01/01/2000 - "This study was designed to see whether S-methylisothiourea sulfate (SMT), a selective inhibitor for iNOS, prevents cardiovascular changes and multiple organ damage in the canine endotoxic shock model. " 01/01/2000 - "S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model." 12/20/1994 - "Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase."
5.	Pain (Aches) 02/01/2013 - "The present study was undertaken in rats to investigate the effect of iNOS inhibitor S-methylisothiourea (SMT) in MIA-induced osteoathritic pain and disease progression in rats. " 10/01/2014 - "The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. " 02/01/2013 - "Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy." 03/01/2008 - "Therefore, in the present study we assessed the nature of the interaction between S-methylisothiourea (a moderately selective iNOS inhibitor) with rofecoxib (selective COX-2 inhibitor) and mefenamic acid (a nonselective COX inhibitor) in formalin- induced pain in mice. " 03/01/2008 - "The dose-response relation of S-methylisothiourea, rofecoxib, mefenamic acid, and their combination was studied in the late phase of formalin-induced pain in mice over the time spent in licking the hindpaw after formalin injection. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	nimesulide (Aulin)
3.	SB 203580
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Peroxidase (Myeloperoxidase)
6.	Mefenamic Acid (Pontal)
7.	rofecoxib (Vioxx)
8.	Peroxynitrous Acid (Peroxynitrite)
9.	omega-N-Methylarginine (NG Monomethyl L Arginine)
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Ligation
3.	Injections
4.	Drug Therapy (Chemotherapy)