1,2-epoxybutane

RN given refers to cpd with unspecified isomeric designation

Also Known As:

1,2-butylene oxide; 1,2-epoxybutane, (+-)-isomer; 1,2-epoxybutane, (R)-isomer; 1,2-epoxybutane, (S)-isomer; 1-butene oxide; oxirane, ethyl-

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - 1,2-epoxybutane: 3

Related Diseases

1.	Carcinogenesis 03/01/1988 - "Two-Year Studies: The 2-year toxicology and carcinogenesis studies of 1,2-epoxybutane were conducted by exposing groups of 50 animals per species and sex to the chemical by inhalation, 6 hours per day 5 days per week. " 03/01/1988 - "NTP Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)."
2.	Neoplasms (Cancer) 10/31/1997 - "Nearly 500 long-term rodent carcinogenicity studies carried out by the National Cancer Institute and the National Toxicology Program were examined, and 12 chemicals were identified that produced nasal tumors: allyl glycidol ether, p-cresidine, 1,2-dibromo-3-chloropropane, 1,2-dibromoethane, 2,3-dibromo-1-propanol, dimethylvinyl chloride, 1,4-dioxane, 1,2-epoxybutane, iodinated glycerol, procarbazine, propylene oxide, and 2,6-xylidine. "
3.	Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar) 03/01/1988 - "Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined). "
4.	Carcinoma (Carcinomatosis) 03/01/1988 - "Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined). "
5.	Adenoma (Adenomas) 03/01/1988 - "Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined). "

Related Drugs and Biologics

1.	Ethylene Dibromide (1,2 Dibromoethane)
2.	Procarbazine (Matulane)
3.	Ether (Diethyl Ether)
4.	Chlorides
5.	1,4-dioxane (dioxane)
6.	2,3-dibromopropanol
7.	iodinated glycerol
8.	cresidine
9.	propylene oxide
10.	2,6-xylidine