flexibilide

cembranoid lactone; structure in first source & in UD 32;123h

Also Known As:

5,15-Dioxatricyclo(12.3.1.0(4,6))octadec-9-en-16-one, 13-hydroxy-4,9,13-trimethyl-17-methylene-, (1R-(1R*,4S*,6S*,9E,13S*,14R*))-

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - flexibilide: 3

Experts

1.	Gao, Dan: 1 article (03/2016)
2.	Guan, Jin: 1 article (03/2016)
3.	Guo, Yuewei: 1 article (03/2016)
4.	Jiang, Yuyang: 1 article (03/2016)
5.	Liu, Hongxia: 1 article (03/2016)
6.	Wang, Yini: 1 article (03/2016)
7.	Xie, Weiyi: 1 article (03/2016)
8.	Yang, Ti: 1 article (03/2016)
9.	Chang, Yu-Chia: 1 article (06/2014)
10.	Chen, Chun-Hong: 1 article (06/2014)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 06/27/2014 - "In the present study, we investigated the antinociceptive properties of flexibilide in the rat chronic constriction injury (CCI) model of neuropathic pain. " 06/27/2014 - "Our results suggest that flexibilide may serve as a therapeutic agent for neuropathic pain. "
2.	Neoplasms (Cancer) 03/01/2016 - "The UPLC/Q-TOF MS based metabolomics approach provides new insights into the mechanistic studies of flexibilide on tumor cells, which benefit its further improvement and application. "
3.	Colonic Neoplasms (Colon Cancer) 03/01/2016 - "Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line."
4.	Inflammation (Inflammations) 06/27/2014 - "The compound flexibilide, which can be obtained from cultured soft coral, possesses anti-inflammatory and analgesic effects in the rat carrageenan peripheral inflammation model. " 09/01/1980 - "Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active after oral administration in both acute and chronic animal models of inflammation. "
5.	Hyperalgesia 06/27/2014 - "administration of 10-μg flexibilide twice daily was able to prevent the development of thermal hyperalgesia and weight-bearing deficits in CCI rats. " 06/27/2014 - "First, we found that a single intrathecal (i.t.) administration of flexibilide significantly attenuated CCI-induced thermal hyperalgesia at 14 days after surgery. "

Related Drugs and Biologics

1.	Carrageenan
2.	Analgesics (Analgesic Drugs)
3.	6-n-tridecylsalicylic acid
4.	dendalone 3-hydroxybutyrate

Related Therapies and Procedures

1.	Oral Administration