protylonolide
structure in first source
Also Known As:
20-DSDR; 20-deoxo-12,13-desepoxy-12,13-dehydrorosaranolide; tylactone; Tylonolide, 20-deoxo-23-deoxy-
Networked: 2
relevant articles (0 outcomes,
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Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Dehydration (Water Stress)
10/27/2010
- " Incubation of a mixture of propionyl-SNAC (4), methylmalonyl-CoA, and NADPH with the DEBS β-ketoacyl synthase-acyl transferase [KS6][AT6] didomain, DEBS ACP6, and the ketoreductase domain from tylactone synthase module 1 (TYLS KR1) generated in situ anti-2a-ACP that underwent DH4-catalyzed syn dehydration to give 3-ACP. " 10/27/2010
- " The recombinant dehydratase domain from NANS module 2, NANS DH2, was shown to catalyze the formation of an (E)-double bond by syn-dehydration of the ACP-bound substrate anti-(2R,3R,4S,5R)-2,4-dimethyl-3,5-dihydroxyheptanoyl-ACP6 (4), generated in situ by incubation of (2S,3R)-2-methyl-3-hydroxypentanoyl-SNAC (5), methylmalonyl-CoA, and NADPH with the recombinant [KS6][AT6] didomain and ACP6 from DEBS module 6 along with the ketoreductase from the tylactone synthase module 1 (TYLS KR1). "
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